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Modulation of paraoxonase activity (PON)-1 by xanthone in sub chronic exposure of orgnophosphate: Antioxidant in dichorvos intoxicity

  • Titin Andri WihastutiEmail author
  • Djanggan Sargowo
  • Teuku Heriansyah
  • Grace Rahmawati
  • Yuni Hendrati Sulfia
Research Article

Abstract

This research aims to find out the levels of xanthone in mangosteen pericarp extract (MPE) and to prove the ability of xanthone in modulating the activity of paraoxonase-1 (PON-1), reduce oxidized-low density lipoprotein (ox-LDL) and increase the levels of acetylcholinesterase (AChE) serum in animal model with organophosphat subchronic and subcutaneous exposure. This research is a true experimental laboratory with in vivo approach to post-test with control group, using 25 animal models of Wistar strain of Rattus novergicus, were exposed to dichlorvos as organophosphates (2 mg/kgBW/day) for 21 days. Those animal models are divided into no exposure group, organophosphate exposure group, and organophosphate exposure plus administration of xanthone groups. The parameters (levels of PON-1, ox-LDL and AChE measured by ELISA Test. The results showed that administration of xanthone significantly increased the levels of AChE, decreased levels of ox-LDL and PON-1.

Keywords

PON-1 ox-LDL AChE Mangosteen pericarp extract Xanthone Organophosphat 

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Copyright information

© Korean Society of Environmental Risk Assessment and Health Science and Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • Titin Andri Wihastuti
    • 1
    Email author
  • Djanggan Sargowo
    • 2
  • Teuku Heriansyah
    • 3
  • Grace Rahmawati
    • 4
  • Yuni Hendrati Sulfia
    • 4
  1. 1.Department of Biomedical, Faculty of MedicineBrawijaya UniversityMalangIndonesia
  2. 2.Department of Cardiology, Faculty of MedicineBrawijaya UniversityMalangIndonesia
  3. 3.Department of Cardiology, Faculty of MedicineSyiah Kuala UniversityAcehIndonesia
  4. 4.Brawijaya UniversityMalangIndonesia

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