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Effects of low frequency electrical stimulation on the change of male sex hormones in normal men

  • Junghwan KimEmail author
Research Article
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Abstract

It is widely known that electrotherapy decreases the pain by mechanical and chemical stimulation. However, there have been no studies to find the change in the sex hormones by acupoint electrical stimulation for healthy rehabilitation. This study examines the effects that electrical stimulation of volunteers’ meridian points has on their levels of total testosterone, dehydroepiandrosterone sulfate (DHEA-S), follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin, and other erectile dysfunction-related substances. A serum analysis showed that electrical stimulation using a 1 Hz current significantly increased the subjects’ concentrations of total testosterone and DHEA-S; however, there were no significant differences in the concentrations of FSH, LH, and prolactin in subjects treated with electrical stimulation. These results suggest that the increased responsiveness to electrical stimulation, particularly a current of 1 Hz continue type, may be partially related to an improvement in sexual functions.

Key words

Testosterone Dehydroepiandrosterone sulfate Low frequency electrical stimulation 

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References

  1. 1.
    Pohl, H., DeRosa, C. & Holler, J. Public health assessment for dioxins exposure from soil. Chemosphere. 31, 2437–2454, 1995.PubMedCrossRefGoogle Scholar
  2. 2.
    Grajewski, B. et al. Evaluation of reproductive function among men occupationally exposed to a stilbene derivative: I. Hormonal and physical status. Am. J. Ind. Med. 29, 49–57, 1996.PubMedCrossRefGoogle Scholar
  3. 3.
    Freeman, K. Arsenic and erectile dysfunction: drinking contaminated well water increases risk. Environ. Health Perspect. 116, A172, 2008.PubMedCrossRefGoogle Scholar
  4. 4.
    Egeland, G. M. et al. Total serum testosterone and gonadotropins in workers exposed to dioxin. Am. J. Epidemiol. 139, 272–281, 1994.PubMedGoogle Scholar
  5. 5.
    Howell, S. & Shalet, S. Testosterone deficiency and replacement. Horm. Res. 56Suppl 1, 86–92, 2001.PubMedCrossRefGoogle Scholar
  6. 6.
    Shabsigh, R. The effects of testosterone on the carverous tissue and erection. World J. Urol. 15, 21–26, 1997.PubMedCrossRefGoogle Scholar
  7. 7.
    Yildrim, M. K. et al. Effects of castration on adrenergic, cholinergic and nonadrenergic, noncholinergic responses of isolated corpus cavernosum from rabbit. Br. J. Urol. 79, 964–970, 1997.CrossRefGoogle Scholar
  8. 8.
    Reilly, C. M., Stopper, V. S. & Mills, T. M. Androgens modulate the α-adrenergic responsiveness of vascular smooth muscle in the corpus carvernosum. J. Androl. 18, 26–31, 1997.PubMedGoogle Scholar
  9. 9.
    Palese, M. A., Crone, J. K. & Burnett, A. L. A castrated mouse model of erectile dysfunction. J. Androl. 24, 699–703, 2003.PubMedGoogle Scholar
  10. 10.
    Korenman, S. G. Clinical review 71: Advances in the understanding and management of erectile dysfunction. J. Clin. Endocrinol. Metab. 80, 1985–1988, 1995.PubMedCrossRefGoogle Scholar
  11. 11.
    Spark, R. F., White, R. A. & Connolly, P. B. Impotence is not always psychogenic. Newer insights into hypothalamic-pituitary-gonadal dysfunction. JAMA. 243, 750–755, 1980.PubMedCrossRefGoogle Scholar
  12. 12.
    Maatman, T. J. & Montague, D. K. Routine endocrine screening in impotence. Urology 27, 499–502, 1986.PubMedCrossRefGoogle Scholar
  13. 13.
    Zietz, B. et al. Association of increased C-peptide serum levels and testosterone in type 2 diabetes. Eur. J. Intern. Med. 11, 322–328, 2000.PubMedCrossRefGoogle Scholar
  14. 14.
    Zhang, X. H. et al. Testosterone restores diabetes-induced erectile dysfunction and sildenafil responsiveness in two distinct animal models of chemical diabetes. J. Sex Med. 3, 253–264, 2006.PubMedCrossRefGoogle Scholar
  15. 15.
    Ebeling, P. & Koivisto, V. A. Physiological importance of dehydroepiandrosterone. Lancet 343, 1479–1481, 1994.PubMedCrossRefGoogle Scholar
  16. 16.
    Reiter, W. J. et al. Serum dehydroepiandrosterone sulfate concentrations in men with erectile dysfunction. Urology 55, 755–758, 2000.PubMedCrossRefGoogle Scholar
  17. 17.
    Hall, R. C. & Hall, R. C. Abuse of supraphysiologic doses of anabolic steroids. South Med. J. 98, 550–555, 2005.PubMedCrossRefGoogle Scholar
  18. 18.
    Anis, T. H. et al. Chronic lead exposure may be associated with erectile dysfunction. J. Sex Med. 4, 1428–1434, 2007.PubMedCrossRefGoogle Scholar
  19. 19.
    Li, D. K. et al. Relationship between urine bisphenol-A level and declining male sexual function. J. Androl. 31, 500–506, 2010.PubMedCrossRefGoogle Scholar
  20. 20.
    Schover, L. R. & von Eschenbach, A. C. Sexual and marital relationships after treatment for nonseminomatous testicular cancer. Urology 25, 251–255, 1985.PubMedCrossRefGoogle Scholar
  21. 21.
    Mehik, A. et al. Fears, sexual disturbances and personality features in men with prostatitis: a population-based cross-sectional study in Finland. BJU. Int. 88, 35–38, 2001.PubMedCrossRefGoogle Scholar
  22. 22.
    Buvat, J. & Lemaire, A. Endocrine screening in 1,022 men with erectile dysfunction: clinical significance and cost-effective strategy. J. Urol. 158, 1764–1767, 1997.PubMedCrossRefGoogle Scholar
  23. 23.
    Wanachiwanawin, W. et al. Prevalence and clinical significance of hepatitis C virus infection in Thai patients with thalassemia. Int. J. Hematol. 78, 374–378, 2003.PubMedCrossRefGoogle Scholar
  24. 24.
    Cai, S. X. et al. Subjective symptom increase among dry-cleaning workers exposed to tetrachloroethylene vapor. Ind. Health. 29, 111–121, 1991.PubMedCrossRefGoogle Scholar
  25. 25.
    Carey, P. O., Howards, S. S. & Vance, M. L. Transdermal testosterone treatment of hypogonadal men. J. Urol. 140, 76–79, 1988.PubMedGoogle Scholar
  26. 26.
    Arver, S. et al. Improvement of sexual function in testosterone deficient men treated for 1 year with a permeation enhanced testosterone transdermal system. J. Urol. 155, 1604–1608, 1996.PubMedCrossRefGoogle Scholar
  27. 27.
    Zheng, X. F. & Li, P. Study on effects of acupuncture combined with medication on reproductive endocrines in the patient of PADAM. Zhongguo. Zhen. Jiu. 27, 333–335, 2007Google Scholar
  28. 28.
    El-Sakka, A. I., Sayed, H. M. & Tayeb, K. A. Androgen pattern in patients with type 2 diabetes-associated erectile dysfunction: impact of metabolic control. Urology 74, 552–559, 2009.PubMedCrossRefGoogle Scholar
  29. 29.
    Tsujita, M. & Ichikawa, Y. Substrate-binding region of cytochrome P-450SCC (P-450 XIA1). Identification and primary structure of the cholesterol binding region in cytochrome P-450SCC. Biochim. Biophys. Acta. 1161, 124–130, 1993.PubMedCrossRefGoogle Scholar
  30. 30.
    Liu, W. H. & Lo, C. K. Production of testosterone from cholesterol using a single-step microbial transformation of Mycobacterium sp. J. Ind. Microbiol. Biotechnol. 19, 269–272, 1997.PubMedCrossRefGoogle Scholar
  31. 31.
    Snyder, P. J. & Lawrence, D. A. Treatment of male hypogonadism with testosterone enanthate. J. Clin. Endocrinol. Metab. 51, 1335–1339, 1980.PubMedCrossRefGoogle Scholar
  32. 32.
    Leonard, M. P., Nickel, C. J. & Morales, A. Hyperprolactinemia and impotence: why, when and how to investigate. J. Urol. 142, 992–994, 1989.PubMedGoogle Scholar
  33. 33.
    Clayton, R. N. Mechanism of GnRH action in gonadotrophs. Hum. Reprod. 3, 479–483, 1988.PubMedGoogle Scholar
  34. 34.
    Lambert, A., Talbot, J. A., Anobile, C. J. & Robertson, W. R. Gonadotrophin heterogeneity and biopotency: implications for assisted reproduction. Mol. Hum. Reprod. 4, 619–629, 1998.PubMedCrossRefGoogle Scholar
  35. 35.
    Richards, J. S. et al. Novel signaling pathways that control ovarian follicular development, ovulation, and luteinization. Recent Prog. Horm. Res. 57, 195–220, 2002.PubMedCrossRefGoogle Scholar
  36. 36.
    Kim, J. H. et al. Noxiousness of hypertension-related norepinephrine and upregulation of norepinephrine induced by high intensity electrical stimulation in healthy volunteers. J. Phys. Ther. Sci. 24, 795–800, 2012.CrossRefGoogle Scholar
  37. 37.
    Urban, R. J. et al. Specific regulatory actions of dihydrotestosterone and estradiol on the dynamics of FSH secretion and clearance in humans. J. Androl. 12, 27–35, 1991.PubMedGoogle Scholar

Copyright information

© Korean Society of Environmental Risk Assessment and Health Science and Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Laboratory of Health Science & Nanophysiotherapy, Department of Physical Therapy, College of Public Health & WelfareYongin UniversityYonginKorea

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