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The effect of oral consumption of sesame oil on anthropometric, metabolic and oxidative stress markers of patients with type 2 diabetes: a double-blind, randomized controlled trial

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International Journal of Diabetes in Developing Countries Aims and scope Submit manuscript

Abstract

Background

Sesame oil has several polyphenols with possible anti-diabetic and antioxidative characteristics. However, there is limited evidence for the efficacy of sesame oil on type 2 diabetes mellitus (T2DM) consequences. 

Objective

We aimed to investigate the effects of sesame oil as one of the safest edible oils and whether it could be an adjuvant therapy to medications in T2DM patients.

Methods

Fifty-six patients with T2DM were enrolled in the study. They were randomly divided into two groups, receiving sesame oil (SO) as the intervention group (n = 28) or sunflower seeds oil (SSO) as the placebo group (n = 28) for 8 weeks. We assessed anthropometric, lipid profile, oxidative stress, and inflammatory indicators. We used paired sample t-test/Wilcoxon test and an unpaired t-test to examine the differences among and between the arms.

Results

The results showed that malondialdehyde (MDA) was reduced significantly in the SO group (1.33 ± 1.26, p = 0.001). However, the results in the SSO group were vice versa, and MDA noticeably increased in the control group after eight weeks (− 2.08 ± 1.01, p < 0.001). Despite the in-group changes, no significant differences were spotted in anthropometric, glycemia, lipid profile, and inflammatory indicators between both intervention and control groups.

Conclusion

Our findings suggest a possible antioxidative effect of sesame oil by decreasing MDA with no effects on other measured outcomes. This is a safe and effective option for relieving oxidative stress, as the supplementation with sesame oil for 8 weeks was not associated with harmful effects.

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Data Availability

The data supporting the findings of this study will be made available upon reasonable request in a scientifically sound manner.

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Acknowledgment

All study authors acknowledge Kashan University of Medical Sciences and Health Services for their financial support of this study.

Funding

This work was financially supported by Kashan University of Medical Sciences and Health Services (Kashan, Iran).

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Authors

Contributions

SJ, NA, and MT conceived the trial and designed the experiment. NA, MT, MS, and SJ assisted with the conduction of the study and wrote the manuscript. SJ supervised the study. All study authors read and approved the final version of the manuscript.

Corresponding author

Correspondence to Sadegh Jafarnejad.

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Competing interests

The authors declare no competing interests.

Ethical approval and Consent of patient

The study protocol was registered at the Iranian Registry of Clinical Trials (IRCT20150920024103N2) and was approved by the Ethics Committee of Kashan University of Medical Sciences (IR.KAUMS.MEDNT.REC.1398.055). At the first clinical visit, the risks and benefits of the study were described in detail, and all participants provided written informed consent. All patients gave oral informed consent before enrolment in the study after fully describing the study procedure to them.

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Tobeiha, M., Amin, N., Shahaboddin, M.E. et al. The effect of oral consumption of sesame oil on anthropometric, metabolic and oxidative stress markers of patients with type 2 diabetes: a double-blind, randomized controlled trial. Int J Diabetes Dev Ctries (2024). https://doi.org/10.1007/s13410-024-01350-4

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