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The effect of 8 weeks of endurance and resistance exercises on the serum levels of FGF23 and s-Klotho in type 2 diabetic women

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International Journal of Diabetes in Developing Countries Aims and scope Submit manuscript

Abstract

Background

It has been reported that exercise could improve diabetes via the VitD-FGF23-sKlotho axis.

Objective

We evaluated the effects of 8 weeks of endurance and resistance training on serum levels of fibroblast growth factor 23 (FGF23), soluble klotho (s-Klotho), 1,25-dihydroxyvitamin D (VitD), and diabetes biomarkers in overweight/obese postmenopausal type 2 diabetic (T2DM) women.

Methods

Thirty overweight/obese postmenopausal women with T2DM were randomly divided into three groups, including endurance exercise (3 days/week of walking and jogging), resistance exercise (60 min weight resistance training 3 days/week), and control groups (no physical activity and dietary change). Before and after the 8-week training, serum levels of FGF23, s-Klotho, VitD, blood sugar, lipid profile, and hemoglobin A1c (HbA1c) as well as anthropometric, physiological, and cardiac characteristics were evaluated.

Results

The endurance or resistance training did not significantly change the anthropometric and cardiac parameters (p > 0.05), and only fat percent, resting heart rate, and systolic blood pressure levels were significantly decreased after the endurance exercise (p < 0.05). Both endurance and training exercises could improve serum levels of insulin and glucose. The serum levels of FGF23 and s-Klotho were significantly increased in the endurance and resistance groups (p < 0.05), while no significant change was found in the VitD levels.

Conclusion

Physical exercises, especially the endurance feature of the training modality, could increase serum FGF23 and s-Klotho levels and decrease FBG and HbA1c levels in postmenopausal T2DM women which might be a sign of improvement in glucose metabolism through regulation of VitD-FGF23-s-klotho axis.

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Acknowledgements

We would like to thank all participants in this study.

Author information

Authors and Affiliations

  1. Department of Sport Health Sciences, Ankara University, Ankara, Turkey

    Niloufar Ghadamyari

  2. Department of Physical Education, Faculty of Sport Sciences, Urmia University, Urmia, Iran

    Mohammad Reza Zolfaghari & Javad Tolouei Azar

  3. Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Amir Fattahi

Authors
  1. Niloufar Ghadamyari
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  2. Mohammad Reza Zolfaghari
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  3. Javad Tolouei Azar
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  4. Amir Fattahi
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Niloufar Ghadamyari, Mohammad Reza Zolfaghari, Javad Tolouei Azar, and Amir Fattahi. The first draft of the manuscript was written by Amir Fattahi and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Mohammad Reza Zolfaghari.

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This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethical Committee of Urmia University.

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Informed consent was obtained from all individual participants included in the study.

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The authors declare no competing interests.

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Ghadamyari, N., Zolfaghari, M.R., Tolouei Azar, J. et al. The effect of 8 weeks of endurance and resistance exercises on the serum levels of FGF23 and s-Klotho in type 2 diabetic women. Int J Diabetes Dev Ctries (2024). https://doi.org/10.1007/s13410-024-01343-3

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