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24-h Glucose profile of patients with gestational diabetes mellitus and comparison with pregnant women with normoglycemia

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International Journal of Diabetes in Developing Countries Aims and scope Submit manuscript

Abstract

Objective

To study the 24-h glucose profile of patients with mild GDM using the commercially available Abbot Libre continuous glucose monitoring system (CGMS) and compare them with pregnant women with normoglycemia (gestational age comparable).

Methods

A case control study conducted between 2019-2020 followed eligible pregnant women diagnosed with GDM according to Diabetes in Pregnancy Study Group India criteria, after the placement of a CGMS.

Results

Twenty-one GDM patients whose mean age was 27.1 ± 3.3 years with gestational age 28 weeks (24–32) and thirty pregnant women with normoglycemia whose mean age was 25.7 ± 4.2 years and gestational age 26 weeks (23–34) were enrolled in the study. Fasting, pre-breakfast, 2 h post lunch, day time and lowest nocturnal glucose were significantly higher in the GDM group than in controls. Glycemic variability indices like standard deviation of blood glucose, J index, and mean amplitude of glycemic excursions were also significantly higher in GDM patients. GDM patients spent more time above >140 mg/dl than controls.

Conclusion

GDM patients, who have mild hyperglycemia but not overt diabetes, also have an abnormal 24 h glucose profile as compared to normal pregnancy.

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Data can be provided on a genuine request.

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Acknowledgments

I would like to acknowledge Prof Eesh Bhatia for his valuable inputs in reviewing the original manuscript, Prabhakar Misra Dr Bibhuti Mohanta for helping in recruiting patients, diabetes nurse in helping with CGMS application and contact with patients.

Funding

DM project funding from Endocrine Society of India (ESI).

Author information

Authors and Affiliations

  1. Department of Endocrinology, Medicine Office, George Medical University, opposite Gandhi ward, Lucknow, 226003, India

    Shiva Madan

  2. Department of Obstetrics and Gynecology, D1221 Indira Nagar, Lucknow, 226016, India

    Manjulata Verma

  3. Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, C BlockRaebareli Road, Lucknow, 226014, India

    Preeti Dabadghao

Authors
  1. Shiva Madan
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  2. Manjulata Verma
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  3. Preeti Dabadghao
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Corresponding author

Correspondence to Preeti Dabadghao.

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Ethical clearance

A case control study conducted in the outpatient clinics of a tertiary care hospital from North India from January 2019 to December 2020. The study was approved by the institutional ethics committee (Reference no. IEC code-2019-108-IMP-109). All women who fulfilled the inclusion criteria were informed about the study and the consenting participants were enrolled.

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The authors declare no competing interests.

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Madan, S., Verma, M. & Dabadghao, P. 24-h Glucose profile of patients with gestational diabetes mellitus and comparison with pregnant women with normoglycemia. Int J Diabetes Dev Ctries 44 (Suppl 1), 27–32 (2024). https://doi.org/10.1007/s13410-024-01311-x

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  • DOI: https://doi.org/10.1007/s13410-024-01311-x

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