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Association of adipokine levels and insulin resistance in prediabetes: hospital-based descriptive study in a tertiary care hospital in North Kerala

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International Journal of Diabetes in Developing Countries Aims and scope Submit manuscript

Abstract

Objective

Increasing evidence revealed the role of adipokines in carbohydrates and fat metabolism. The present study was designed to evaluate the adiponectin, leptin, and resistin levels in prediabetes subjects and evaluate the relationship between these adipokines and insulin resistance.

Methods

A hospital-based descriptive study was conducted for one year. 200 individuals who met the inclusion criteria were enrolled in the study. Based on the oral glucose tolerance test, the study subjects were grouped into healthy controls (n = 100), prediabetic non-obese (n = 61), and prediabetic obese (n = 39). Blood glucose estimation was done by the glucose oxidase peroxidase method. Chemiluminescent immunoassay was used for the measurement of insulin level and homeostasis model assessment-estimated insulin resistance was used for the assessment of insulin resistance. Serum adipokines levels were determined by ELISA. Statistical analysis was performed by using SPSS Software.

Results

Serum adiponectin levels decreased significantly in obese prediabetes (7.21 ± 2.15 µg/ml) when compared to non-obese prediabetes (7.28 ± 2.41 µg/ml) and healthy control subjects (13.64 ± 2.88 µg/ml, p < 0.001). Serum leptin levels increased significantly in obese prediabetes (13.59 ± 2.59 ng/ml) when compared to non-obese prediabetes (9.84 ± 2.66 ng/ml) and healthy control subjects (12.28 ± 2.65 ng/ml, p < 0.001). Serum resistin levels increased significantly in obese prediabetes (17.67 ± 3.60 ng/ml) when compared to non-obese prediabetes (17.2 ± 3.93 ng/ml) and healthy control subjects (14.46 ± 4.16 ng/ml, p < 0.001). Adiponectin-leptin ratio decreased significantly in obese prediabetes (0.56 ± 0.22) when compared to non-obese prediabetes (0.79 ± 0.4) and healthy control subjects (1.15 ± 0.37; p < 0.001). Fasting insulin resistance was statistically significant (p < 0.001) in all groups.

Conclusion

The present study strongly suggests that the adipokine profile is an ideal diagnostic tool to predict prediabetes and metabolic syndrome, especially among those with insulin resistance.

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Acknowledgments

The authors express our sincere gratitude to all the participants for their immense support and cooperation in this study.

Funding

Self-funded.

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Authors and Affiliations

  1. School of Allied Medical Sciences, Lovely Professional University, Phagwara, Punjab, India

    C. P. Bineesh & Pranav Kumar Prabhakar

  2. Department of Endocrinology, Aster MIMS Hospital, Calicut, Kerala, India

    M. V. Vimal

  3. Department of Transplantation Immunology and Molecular Biology, Aster MIMS Hospital, Calicut, Kerala, India

    Vipin Viswanath

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  1. C. P. Bineesh
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  2. M. V. Vimal
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  3. Vipin Viswanath
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  4. Pranav Kumar Prabhakar
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Contributions

Study design (A), Data collection (B), Statistical analysis (C), Data interpretation (D), Manuscript preparation (E), Literature search (F), Fund collection. (ABCDEFG)- 1 Bineesh C P, (ACDEF)- 2 Pranav Kumar Prabhakar, (ACD)- 3 M. V. Vimal and (BEF)- 4 Vipin Viswanath.

Corresponding author

Correspondence to Pranav Kumar Prabhakar.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Authors declare no conflict of interests.

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Name of the department and institution where work was done: Department of Biochemistry, Aster MIMS Hospital, Calicut, Kerala, India

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Bineesh, C.P., Vimal, M.V., Viswanath, V. et al. Association of adipokine levels and insulin resistance in prediabetes: hospital-based descriptive study in a tertiary care hospital in North Kerala. Int J Diabetes Dev Ctries (2023). https://doi.org/10.1007/s13410-023-01248-7

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  • DOI: https://doi.org/10.1007/s13410-023-01248-7

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