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The risk factors of early arterial stiffness in type 2 diabetes without diabetic macroangiopathy

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International Journal of Diabetes in Developing Countries Aims and scope Submit manuscript

Abstract

Background

Type 2 diabetes exposes the body to a state of high blood sugar for a long time and causes varying degrees of hardening of the arteries, making it more prone to cardiovascular emergencies.

Objective

The aim of the study was to explore the risk factors of early arterial stiffness in patients with type 2 diabetes mellitus (T2DM).

Methods

A retrospective study was conducted on 316 T2DM patients without macroangiopathy in The First Hospital of Qinhuangdao. Early arterial stiffness was evaluated by brachial-ankle pulse wave velocity (baPWV).

Results

Ninety patients (28.5%) had baPWV≥1800cm/s. baPWV showed positive correlation with systolic blood pressure (r=0.456, p<0.001), diastolic blood pressure (r=0.133, p=0.018), urine albumin-creatinine ratio (UACR) (r=0.232, p<0.001), neutrophil lymphocyte ratio (NLR) (r=0.185, p=0.001), and visceral fat area (r=0.139, p=0.014). In multiple linear regression analysis, systolic blood pressure (β=6.240, p<0.001), UACR (β=3.805, p=0.019), NLR (β=43.722, p=0.013), and visceral fat area (β=0.778, p=0.030) were significant independent predictors for baPWV.

Conclusion

The decline of arterial elasticity was common in T2DM patients without macroangiopathy. Elevated blood pressure, microangiopathy, chronic inflammation, and visceral fat accumulation were the risk factors of early arterial stiffness in patients with T2DM.

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Data Availability

The data that support the findings of this study are available from the corresponding author, [Chun-Ming Ma], upon reasonable request.

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, Hebei North University, Hebei Province, Zhangjiakou, China

    Jia-Hui Wu

  2. Department of Endocrinology, The First Hospital of Qinhuangdao affiliation with Hebei North University, Hebei Province, Qinhuangdao, China

    Jia-Hui Wu

  3. Department of Endocrinology, The First Hospital of Qinhuangdao, No. 258 Wenhua Road, Qinhuangdao, 066000, Hebei Province, China

    Rui Wang, Xiao-Jiao Jia, Na Lu, Qiang Lu, Fu-Zai Yin & Chun-Ming Ma

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Correspondence to Chun-Ming Ma.

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We declare that submitted manuscript does not contain previously published material, and are not under consideration for publication elsewhere. Each author has made an important scientific contribution to the study and is thoroughly familiar with the primary data. All authors listed have read the complete manuscript and have approved submission of the paper. The manuscript is truthful original work without fabrication, fraud, or plagiarism.

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The present study showed that the decline of arterial elasticity was common in type 2 diabetes patients. Elevated blood pressure, microangiopathy, chronic inflammation, and visceral fat accumulation were the risk factors of early arterial stiffness in patients with type 2 diabetes.

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Wu, JH., Wang, R., Jia, XJ. et al. The risk factors of early arterial stiffness in type 2 diabetes without diabetic macroangiopathy. Int J Diabetes Dev Ctries (2023). https://doi.org/10.1007/s13410-023-01220-5

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