Abstract
Purpose
In this study, we analyzed the effect of stress hyperglycemia on patients admitted with diabetes mellitus. The effects of glycated hemoglobin (HbA1c) on left ventricular function and inflammatory factors in these patients with diabetes mellitus and myocardial infarction undergoing percutaneous coronary intervention (PCI) were also studied.
Methods
The clinical data of 160 patients with diabetes mellitus and myocardial infarction treated with PCI over the period of December 2018 to June 2020 were retrospectively analyzed. The patients were divided into groups A (38 cases), B (40 cases), C (43 cases), and D (39 cases) according to their blood glucose (AG) and HbA1c levels upon admission.
Results
The levels of FGB, 2hPG, and HbA1c in group B after PCI were significantly higher than those in groups A, C, and D (p < 0.05). After PCI, group B showed significantly higher levels of LVESD and LVEDD and significantly lower levels of LVEF than other groups (p < 0.05). The levels of TNF-α, IL-6, and CRP in group B after PCI were significantly higher than those in other groups (p < 0.05). The incidence of endpoint events was higher in group B (35.00%) than in the other three groups (p < 0.05). Multiple logistic regression analysis indicated that high AG and HbA1c levels were the main risk factors for adverse prognosis (p < 0.05). AG and HbA1c were positively correlated with LVESD, LVEDD, TNF-α, IL-6, and CRP levels, and negatively correlated with LVEF levels (p < 0.05).
Conclusions
In summary, in patients with diabetes mellitus combined with myocardial infarction and undergoing PCI on admission, stress hyperglycemia and high HbA1c levels were associated with higher FGB and 2hPG levels, which exacerbate ventricular functional impairment and inflammatory response, increase the risk of endpoint events, and can be predictors of patient prognosis.
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YYZ wrote draft. YYZ and JW designed the study and reviewed the manuscript. TH and QHY collected the data. QZ and XD performed the statistical analysis. All authors read and approved the final manuscript.
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Zhang, Y., Wu, J., Huang, T. et al. Effect of stress hyperglycemia on admission and glycosylated hemoglobin on left ventricular function and inflammatory factors in patients with diabetes mellitus combined with myocardial infarction undergoing PCI. Int J Diabetes Dev Ctries 43, 412–418 (2023). https://doi.org/10.1007/s13410-022-01090-3
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DOI: https://doi.org/10.1007/s13410-022-01090-3