Abstract
Objective
Passive smoking is associated with an increased risk of type 2 diabetes (T2DM). We tested whether the protein tyrosine phosphatase receptor type D (PTPRD) gene rs17584499 single-nucleotide polymorphism is associated with (T2DM) and whether its interaction with passive smoking affects women’s susceptibility to T2DM.
Methods
The subjects were from a community-based survey conducted in Nanchang, China, between May 2017 and June 2018. The study included 160 women with 79 T2DM patients as the T2DM group and 81 healthy volunteers without diabetes as the control group. Peripheral blood genomic DNA was extracted to detect the genotype of the target site of the PTPRD gene. Logistic regression analysis was performed to study the association between the rs17584499 SNP and the risk of T2DM and to analyse the influence of the interaction between genes and passive smoking on susceptibility to T2DM.
Results
After adjusting for age, LDL-C, HDL-C, TC, TG, FINS, IL-18, hs-CRP, and cotinine, binary logistic regression analysis did not find a significant association between rs17584499 and susceptibility to diabetes. After stratifying according to passive smoking, we found that passive smoking women with the CT/TT genotype had a higher risk of T2DM compared with the CC genotype (OR = 3.50, 95 % CI = 1.18~10.44, p = 0.02), but no significant difference was found in non-passive smoking.
Conclusions
This study shows that the T allele of rs17584499 may be a risk factor for female T2DM and that there is a synergistic effect between passive smoking and PTPRD rs17584499 on the susceptibility to T2DM among females.
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Data availability
The data are available from the corresponding authors.
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Acknowledgment
We are grateful to The Second Affiliated Hospital of Nanchang University for approval for this study. We also thank all participants for their willingness to participate in this study.
Funding
National Natural Science Foundation of China (NO. 81560554); Natural Science Foundation of Jiangxi Province (NO. 20144BAB2050007)
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Haixia Zeng, Gui Pan, Juan Wu, and Yanting Huang collected the data. Xiaojun Zhou, Xiaoyang Lai, and Jianping Liu applied for research grants, designed the study, interpreted the data, and revised the manuscript. Haixia Zeng wrote the manuscript. All the authors reviewed the manuscript.
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Approval for the study was obtained from the Clinical Ethics Committee of The Second Affiliated Hospital of Nanchang University. All of the patients and their guardians have given their written informed consent.
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The authors declare no competing interests.
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Zeng, H., Pan, G., Wu, J. et al. Interaction of PTPRD (rs17584499) polymorphism with passive smoking in Chinese women with susceptibility to type 2 diabetes. Int J Diabetes Dev Ctries 43, 304–308 (2023). https://doi.org/10.1007/s13410-022-01078-z
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DOI: https://doi.org/10.1007/s13410-022-01078-z