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Sarcopenia in patients with type 2 diabetes mellitus: a case–control study in Maracaibo city, Venezuela

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International Journal of Diabetes in Developing Countries Aims and scope Submit manuscript

Abstract

Background/purpose of the study

Several studies implicate skeletal muscle as a physio-pathological target among the metabolic disturbances of diabetes, or with the mechanisms shared by sarcopenia and type 2 diabetes mellitus (T2DM). The present study aimed to determine the relationship between sarcopenia and T2DM in outpatients of the Zulian Diabetes Institute, Maracaibo, Venezuela.

Methods

A case–control study was performed on patients diagnosed with T2DM that went to the Zulian Diabetes Institute between January and June 2019. After obtaining a final sample of 131 patients with T2DM, control subjects were selected in a 1:1 ratio according to sex. The European Working Group on Sarcopenia in Older People (EWGSOP) criteria were followed to diagnose sarcopenia, so muscle mass, muscle strength, and muscle performance were determined.

Results

A total of 261 patients were evaluated (131 with T2DM and 131 controls), with no differences in mean age (with T2DM 63.6 ± 9.3 vs. controls 63.6 ± 9.4 years old; p = 0.99). The prevalence of sarcopenia in control subjects was 9.9% and in subjects with diabetes 25.2%; p < 0.01; decreased muscle strength was the component with the most significant difference within the two groups (controls 16.8% vs. T2DM 49.6%; p < 0.01). In the multivariate analysis, subjects with worse metabolic control had a greater risk of sarcopenia (OR, 3.31; 95%CI, 1.10–9.97; p = 0.03).

Conclusion

The prevalence of sarcopenia was higher in subjects with T2DM, especially in those with worse metabolic control and normal weight status.

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Authors and Affiliations

  1. Instituto Zuliano de Diabetes, Programa de Especialización en Medicina Interna, Hospital General del Sur “Dr. Pedro Iturbe”, Maracaibo, Venezuela

    Onofre Pineda, Victoria Stepenka & Juan Salazar

  2. Department of Endocrinology and Nutrition, Gregorio Marañón General University Hospital, Madrid, Spain

    Alejandra Rivas-Motenegro & Roberto Añez

  3. Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, 4004, Venezuela

    Nelson Villasmil-Hernandez & Juan Salazar

Authors
  1. Onofre Pineda
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  2. Victoria Stepenka
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  3. Alejandra Rivas-Motenegro
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  4. Nelson Villasmil-Hernandez
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  5. Roberto Añez
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  6. Juan Salazar
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Corresponding author

Correspondence to Juan Salazar.

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Each patient selected to be included in the study received a comprehensive explanation of the study, and their authorization was requested via a written informed consent before they participated in the study.

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Pineda, O., Stepenka, V., Rivas-Motenegro, A. et al. Sarcopenia in patients with type 2 diabetes mellitus: a case–control study in Maracaibo city, Venezuela. Int J Diabetes Dev Ctries 42, 203–210 (2022). https://doi.org/10.1007/s13410-021-00989-7

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  • DOI: https://doi.org/10.1007/s13410-021-00989-7

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