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Combination of negative pressure wound therapy using vacuum-assisted closure and ozone water flushing for treatment of diabetic foot ulcers

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International Journal of Diabetes in Developing Countries Aims and scope Submit manuscript

Abstract

Objective

To investigate the efficacy of negative pressure wound therapy (NPWT) using vacuum-assisted closure (VAC) and ozone water flushing for the treatment of diabetic foot ulcers.

Methods

The present study included 136 consecutive diabetic foot ulcers (DFUs) patients who went to our hospital during April 2016 to August 2017. The patients were randomly divided into two groups: the combined group in which patients received both VAC and ozone water flushing, and the VAC group in which patients received only VAC. Clinical outcomes were recorded and the change of the wound surface area was calculated. The pain condition was evaluated using the visual analogue scale (VAS) scores.

Results

The duration of the treatment was significantly shorter and the dressing change times and peak VAS scores were both dramatically lower in the combined group than the VAC group. The reduction of the wound surface area was significantly larger after 1-week, 2-week, and 3-week treatment in the combined group; however, no significant difference was found after 1-month treatment. The bacterial clearance rate was significantly higher after 2-week treatment in the combined group compared with the VAC group; however, no significant difference was found after the whole treatment. No significant difference was observed in the recurrence and amputation rates.

Conclusion

The combination use could enhance the recovery of DFUs, shorten the treatment duration, and reduce the pain during treatment.

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Funding

This work was supported by the project of Lnc-MALAT1 which regulates the homing and biological function mechanism of endothelial progenitor cells in diabetic vascular disease (No. 81671793) and the Fundamental Research Funds for the Central Universities (No. 22120170092).

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Authors and Affiliations

  1. Interventional Vascular Surgery, Tenth People’s Hospital Affiliated to Tongji University, Tongji University School of Medicine, Shanghai, 200072, China

    Xiaoxiao Hu, Yebin Ni, Weishuai Lian, Li Kang & Maoquan Li

  2. Emergency Department, Tenth People’s Hospital Affiliated to Tongji University, Tongji University School of Medicine, Shanghai, 200072, China

    Jinxia Jiang

Authors
  1. Xiaoxiao Hu
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  2. Yebin Ni
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  3. Weishuai Lian
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  4. Li Kang
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  5. Jinxia Jiang
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  6. Maoquan Li
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Corresponding authors

Correspondence to Jinxia Jiang or Maoquan Li.

Ethics declarations

Informed consent was obtained from all patients. The present study was approved by the Ethics Committee of the Shanghai Tenth People’s Hospital.

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The authors declare that they have no conflict of interest.

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Xiaoxiao Hu, Yebin Ni, and Weishuai Lian are co-first authors.

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Hu, X., Ni, Y., Lian, W. et al. Combination of negative pressure wound therapy using vacuum-assisted closure and ozone water flushing for treatment of diabetic foot ulcers. Int J Diabetes Dev Ctries 40, 290–295 (2020). https://doi.org/10.1007/s13410-019-00769-4

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  • DOI: https://doi.org/10.1007/s13410-019-00769-4

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