Calorie restriction is emerging as a tool to achieve remission in type 2 diabetes mellitus. We conducted a clinical trial to assess its effectiveness and durability in our setting.
This was a single-arm clinical trial (CTRI/2017/05/008711) conducted at JIPMER hospital, Pondicherry. Nine adult patients with type 2 diabetes mellitus and with a BMI of more than 23 kg/m2 were included into the study from December 2016. They were admitted to the hospital and given a 700 kcal per day balanced diet for 1 week following which either weight maintaining or weight reducing diet was advised. Patients were followed up monthly for the initial 3 months and were reassessed later after 12 months.
One patient was lost to follow-up and hence results have been provided for eight patients. The mean age was 50.5 years. All patients were males. The duration of diabetes was a median of 2.5 years. All patients tolerated the low calorie diet. The mean weight loss was 4.2 kg after a median of 12 months. The average HbA1c declined from a baseline value of 7.98% to 7.13% after a median of 12 months (p = 0.27). Four patients were off any antidiabetic medication at 12 months of follow-up.
The intervention of a short duration of calorie restriction may be effective in reducing HbA1C in overweight patients with diabetes and the effect can last for a year.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Ardestani A, Rhoads D, Tavakkoli A. Insulin Cessation and Diabetes remission after bariatric surgery in adults with Insulin-treated type 2 diabetes. Diabetes Care. 2015;38:659–64.
Lim EL, Hollingsworth KG, Aribisala BS, Chen MJ, Mathers JC, Taylor R. Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol. Diabetologia. 2011;54:2506–14.
Taylor R. Banting memorial lecture 2012 reversing the twin cycles of type 2 diabetes. Diabet Med. 2013;30:267–75.
Lean ME, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, et al. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. Lancet. 2018;391:541–51.
Bhatt AA, Choudhari PK, Mahajan RR, Sayyad MG, Pratyush DD, Hasan I, et al. Effect of a low-calorie diet on restoration of normoglycemia in obese subjects with type 2 diabetes. Indian J Endocrinol Metab. 2017;21:776–80.
Sellahewa L, Khan C, Lakkunarajah S, Idris I. A systematic review of evidence on the use of very low calorie diets in people with diabetes. Curr Diabetes Rev. 2017;13:35–46.
Steven S, Hollingsworth KG, Al-Mrabeh A, Avery L, Aribisala B, Caslake M, et al. Very-low-calorie diet and 6 months of weight stability in type 2 diabetes: pathophysiologic changes in responders and nonresponders. Diabetes Care. 2016;39:808–15.
Rehackova L, Arnott B, Araujo-Soares V, Adamson AA, Taylor R, Sniehotta FF. Efficacy and acceptability of very low energy diets in overweight and obese people with type 2 diabetes mellitus: a systematic review with meta-analyses. Diabet Med. 2016;33:580–91.
Bantle JP, Wylie-Rosett J, Albright AL, Apovian CM, Clark NG, Franz MJ, et al. Nutrition recommendations and interventions for diabetes: a position statement of the American Diabetes Association. Diabetes Care. 2008;31:S61–78.
Conflict of interest
The authors declare that they have no conflict of interest.
Ethics approval and consent to participate
The study was approved by the Institute Ethics Committee (JIP/IEC/2016/1150) and written informed consent was obtained from all the participants.
All procedures performed in this study were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments.
Consent for publication
Not applicable as this contains only de-identified information.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
Thomas, N.D., Shamanna, S.B. Impact of calorie restriction on glycemic control in overweight patients with type 2 diabetes mellitus. Int J Diabetes Dev Ctries 39, 547–550 (2019). https://doi.org/10.1007/s13410-018-0706-2
- Very low calorie diet
- Type 2 diabetes mellitus