Impact of calorie restriction on glycemic control in overweight patients with type 2 diabetes mellitus



Calorie restriction is emerging as a tool to achieve remission in type 2 diabetes mellitus. We conducted a clinical trial to assess its effectiveness and durability in our setting.


This was a single-arm clinical trial (CTRI/2017/05/008711) conducted at JIPMER hospital, Pondicherry. Nine adult patients with type 2 diabetes mellitus and with a BMI of more than 23 kg/m2 were included into the study from December 2016. They were admitted to the hospital and given a 700 kcal per day balanced diet for 1 week following which either weight maintaining or weight reducing diet was advised. Patients were followed up monthly for the initial 3 months and were reassessed later after 12 months.


One patient was lost to follow-up and hence results have been provided for eight patients. The mean age was 50.5 years. All patients were males. The duration of diabetes was a median of 2.5 years. All patients tolerated the low calorie diet. The mean weight loss was 4.2 kg after a median of 12 months. The average HbA1c declined from a baseline value of 7.98% to 7.13% after a median of 12 months (p = 0.27). Four patients were off any antidiabetic medication at 12 months of follow-up.


The intervention of a short duration of calorie restriction may be effective in reducing HbA1C in overweight patients with diabetes and the effect can last for a year.

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Author information




SBS: concepts, design, literature search, statistical analysis, manuscript preparation, manuscript editing, and manuscript review; NDT: literature search, clinical studies, data acquisition, data analysis, statistical analysis, manuscript preparation. Both the authors have read and approved the final manuscript.

Corresponding author

Correspondence to Suryanarayana Bettadpura Shamanna.

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The authors declare that they have no conflict of interest.

Ethics approval and consent to participate

The study was approved by the Institute Ethics Committee (JIP/IEC/2016/1150) and written informed consent was obtained from all the participants.

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All procedures performed in this study were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments.

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Thomas, N.D., Shamanna, S.B. Impact of calorie restriction on glycemic control in overweight patients with type 2 diabetes mellitus. Int J Diabetes Dev Ctries 39, 547–550 (2019).

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  • Very low calorie diet
  • Type 2 diabetes mellitus
  • Durability