Impact of calorie restriction on glycemic control in overweight patients with type 2 diabetes mellitus

Abstract

Introduction

Calorie restriction is emerging as a tool to achieve remission in type 2 diabetes mellitus. We conducted a clinical trial to assess its effectiveness and durability in our setting.

Methods

This was a single-arm clinical trial (CTRI/2017/05/008711) conducted at JIPMER hospital, Pondicherry. Nine adult patients with type 2 diabetes mellitus and with a BMI of more than 23 kg/m2 were included into the study from December 2016. They were admitted to the hospital and given a 700 kcal per day balanced diet for 1 week following which either weight maintaining or weight reducing diet was advised. Patients were followed up monthly for the initial 3 months and were reassessed later after 12 months.

Results

One patient was lost to follow-up and hence results have been provided for eight patients. The mean age was 50.5 years. All patients were males. The duration of diabetes was a median of 2.5 years. All patients tolerated the low calorie diet. The mean weight loss was 4.2 kg after a median of 12 months. The average HbA1c declined from a baseline value of 7.98% to 7.13% after a median of 12 months (p = 0.27). Four patients were off any antidiabetic medication at 12 months of follow-up.

Conclusion

The intervention of a short duration of calorie restriction may be effective in reducing HbA1C in overweight patients with diabetes and the effect can last for a year.

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Affiliations

Authors

Contributions

SBS: concepts, design, literature search, statistical analysis, manuscript preparation, manuscript editing, and manuscript review; NDT: literature search, clinical studies, data acquisition, data analysis, statistical analysis, manuscript preparation. Both the authors have read and approved the final manuscript.

Corresponding author

Correspondence to Suryanarayana Bettadpura Shamanna.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethics approval and consent to participate

The study was approved by the Institute Ethics Committee (JIP/IEC/2016/1150) and written informed consent was obtained from all the participants.

Ethics statement

All procedures performed in this study were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments.

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Not applicable as this contains only de-identified information.

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Thomas, N.D., Shamanna, S.B. Impact of calorie restriction on glycemic control in overweight patients with type 2 diabetes mellitus. Int J Diabetes Dev Ctries 39, 547–550 (2019). https://doi.org/10.1007/s13410-018-0706-2

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Keywords

  • Very low calorie diet
  • Type 2 diabetes mellitus
  • Durability