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Association of vitamin D deficiency and type 1 diabetes mellitus: a systematic review and meta-analysis

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Abstract

Some studies have suggested that vitamin D deficiency may be associated with autoimmune diseases such as type 1 diabetes mellitus (T1DM). The objectives of this review were to perform a systematic review and meta-analysis and to assess the association between vitamin D deficiency and T1DM. PubMed, Web of Science, Lilacs, and Scielo databases were used to search the articles. The eligibility criteria were cohort, case-control, or cross-sectional observational studies, which assessed the association between vitamin D deficiency and T1DM, comparing T1DM patients with control group. Cross-sectional studies that compared means of vitamin D levels between T1DM patients and control group were included in the first meta-analysis, and cross-sectional studies that compared frequency of vitamin D deficiency between T1DM patients and control group were included in the second meta-analysis. Thirteen studies were included in the systematic review. Most studies (n = 12) compared vitamin D levels between T1DM patients and control group and 75% of them (n = 9) found lower vitamin D levels in T1DM patients. Over half studies (n = 8) compared vitamin D deficiency frequency between T1DM patients and control group and 50% (n = 4) of them observed a higher frequency of vitamin D deficiency in T1DM patients. Meta-analysis demonstrated a significant difference of vitamin D levels between T1DM patients and control group (difference between means = 0.739 ± 0.067, p < 0.001) and that there is a significant association of vitamin D deficiency and T1DM [OR = 1.640 (1.18–1.28), p = 0.003]. There is a significant association between vitamin D deficiency and T1DM.

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References

  1. Diretrizes da Sociedade Brasileira de Diabetes (2015-2016)/Adolfo Milech et al. Organização José Egidio Paulo de Oliveira, Sérgio Vencio - São Paulo: A.C. Farmacêutica; 2016.

  2. lberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. DiabetMed. 1998;15(7):539–553.

  3. American Diabetes Association (ADA). Standards of medical Care in Diabetes. Diabetes Care. 2016;39(Supplement 1):S4–5.

    Article  CAS  Google Scholar 

  4. Sesterheim P, Saitovitch D, Staub HL. Diabetes mellitus tipo 1: Multifatores que conferem suscetibilidade à patogenia autoimune. Sci Med. 2007;17(4):212–7.

    Google Scholar 

  5. Daga RA, Laway BA, Shah ZA, Mir AS, Kotwal SK, Zargar AH. Alta Prevalência De Deficiência De Vitamina D Entre Casos De Diabetes De Início Na Juventude Recém-Diagnosticada No Norte Da Índia. Arq Bras Endocrinol Metab. 2012;56(7):423–8. https://doi.org/10.1590/S0004-27302012000700003.

    Article  Google Scholar 

  6. Azab SFA, Saleh SH, Elsaeed WF, Abdelsalam SM, Ali AA, Esh AMH, et al. Status in diabetic Egyptian children and adolescents: a case-control study. Ital J Pediatr. 2013;39(1):73. https://doi.org/10.1186/1824-7288-39-73.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. Bener A, Alsaied A, Al-Ali M, Al-Kubaisi A, Basha B, Abraham A, et al. High prevalence of vitamin D deficiency in type 1 diabetes mellitus and healthy children. Acta Diabetol. 2009;46(3):183–9. https://doi.org/10.1007/s00592-008-0071-6.

    Article  PubMed  CAS  Google Scholar 

  8. Castro LCG. The vitamin D endocrine system. Arq Bra Endocrinol Metabol. 2011;55(8):566–75. https://doi.org/10.1590/S0004-27302011000800010.

    Article  Google Scholar 

  9. Marques CDL, Dantas AT, Fragoso TS, Duarte ALBP. A importância dos níveis de vitamina D nas doenças autoimunes. Rev Bras Reumatol. 2010;50(1):67–80. https://doi.org/10.1590/S0482-50042010000100007.

    Article  PubMed  Google Scholar 

  10. Peters BSE, Martini LA. Funções Plenamente Reconhecidas de Nutrientes - Vitamina D. Brasil: International Life Sciences Institute Brasil (ILSI); 2014.

    Google Scholar 

  11. Feng R, Yanchuan L, Guogiang L, Zhen L, Yingfeng Z, Qiang L, et al. Lower serum 25(OH)D concentrations in type 1 diabetes: a meta-analysis. Diabetes Res Clin Pract. 2015;108(3):e71–5. https://doi.org/10.1016/j.diabres.2014.12.008.

    Article  PubMed  CAS  Google Scholar 

  12. Moher D, Liberati A, Tetzlaff J, Altman DG. The PRISMA group preferred reporting items for systematic reviews and meta- analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097. https://doi.org/10.1371/journal.pmed.1000097.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Cadario F, Savastio S, Pagliardini V, Bagnati M, Vidali M, Cerutti F, et al. Vitamin D levels at birth and risk of type 1 diabetes in childhood: a case–control study. Acta Diabetol. 2015;52(6):1077–81. https://doi.org/10.1007/s00592-015-0772-6.

    Article  PubMed  CAS  Google Scholar 

  14. Franchi B, Piazza M, Sandri M, Mazzei F, Maffeis C, Boner AL. Vitamin D at the onset of type 1 diabetes in Italian children. Eur Jour Pediatr. 2014;173(4):477–82. https://doi.org/10.1007/s00431-013-2204-3.

    Article  CAS  Google Scholar 

  15. Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, Yakout SM, Aljohani NJ, et al. Lower vitamin D status is more common among Saudi adults with diabetes mellitus type 1 than in non-diabetics. BMC Public Health. 2014;14(1):153. https://doi.org/10.1186/1471-2458-14-153.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  16. Greer RM, Portelli SL, Hung BS, Cleghorn GJ, McMahon SK, Batch JA, et al. Serum vitamin D levels are lower in Australian children and adolescents with type 1 diabetes than in children without diabetes. Pediatr Diabetes. 2013;14(1):31–41. https://doi.org/10.1111/j.1399-5448.2012.00890.x.

    Article  PubMed  CAS  Google Scholar 

  17. Gorham ED, Garland CF, Burgi AA, Mohr SB, Zeng K, Hofflich H, et al. Lower prediagnostic serum 25-hydroxyvitamin D concentration is associated with higher risk of insulin-requiring diabetes: a nested case–control study. Diabetologia. 2012;55(12):3224–7. https://doi.org/10.1007/s00125-012-2709-8.

    Article  PubMed  CAS  Google Scholar 

  18. Ghandchi Z, Neyestani TR, Yaraghi AAS, Eshraghian MR, Gharavi A, Shariatzadeh N, et al. Vitamin D status and the predictors of circulating T helper 1-type immunoglobulin levels in Iranian subjects with type 1 diabetes and their siblings: a case-control study. J Hum Nutr Diet. 2012;25(4):365–72. https://doi.org/10.1111/j.1365-277X.2012.01228.x.

    Article  PubMed  CAS  Google Scholar 

  19. Bin-Abbas BS, Jabari MA, Issa SD, Al-Fares AH, Al-Muhsen S. Vitamin D levels in Saudi children with type 1 diabetes. Saudi Med J. 2011;32(6):589–92.

    PubMed  Google Scholar 

  20. Borkar VV, Devidayal, Verma S, Bhalla AK. Low levels of vitamin D in north Indian children with newly diagnosed type 1 diabetes. Pediatr Diabetes. 2010;11(5):345–50. https://doi.org/10.1111/j.1399-5448.2009.00589.x.

    Article  PubMed  CAS  Google Scholar 

  21. Bierschenk L, Alexander J, Wasserfall C, Haller M, Schatz D, Atkinson M, et al. Vitamin D levels in subjects with and without type 1 diabetes residing in a solar rich environment. Diabetes Care. 2009;32(11):1977–9. https://doi.org/10.2337/dc09-1089.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  22. Littorin B, Blom P, Schölin A, Arnqvist HJ, Blohmé G, Bolinder J, et al. Lower levels of plasma 25-hydroxyvitamin D among young adults at diagnosis of autoimmune type 1 diabetes compared with control subjects: results from the nationwide diabetes incidence study in Sweden (DISS). Diabetologia. 2006;49(12):2847–52. https://doi.org/10.1007/s00125-006-0426-x.

    Article  PubMed  CAS  Google Scholar 

  23. Pozzilli P, Manfrini S, Crinò A, Picardi A, Leomanni C, Cherubini V. Low levels of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 in patients with newly diagnosed type 1 diabetes. Horm Metab Res. 2005;37(11):680–3. https://doi.org/10.1055/s-2005-870578.

    Article  PubMed  CAS  Google Scholar 

  24. Bellastella G, Maiorino MI, Petrizzo M, De Bellis A, Capuano A, Esposito K, et al. Vitamin D and autoimmunity: what happens in autoimmune polyendocrine syndromes? J Endocrinol Investig. 2015;38(6):629–33. https://doi.org/10.1007/s40618-014-0233-z.

    Article  CAS  Google Scholar 

  25. Dahlquist G, Vitamin D. Supplement in early childhood and risk for type I (insulin-dependent) diabetes mellitus (the EURODIAB substudy 2 study group). Diabetologia. 1999;42(1):51–4.

    Article  Google Scholar 

  26. Hyppönen E, Läärä E, Reunanen A, Järvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet. 2001;358(9292):1500–3. https://doi.org/10.1016/S0140-6736(01)06580-1.

    Article  PubMed  Google Scholar 

  27. Makinen M, Simell V, Mykkanen J, Ilonen J, Veijola R, Hyotv H, et al. An increase in serum 25-hydrozyvitamin D concentrations preceded a plateau in type 1 diabetes incidence in Finnish children. J Clin Endocrinol Metab. 2014;99(11):E2353–6. https://doi.org/10.1210/jc.2014-1455.

    Article  PubMed  CAS  Google Scholar 

  28. Mohr SB, Garland FC, Garland CF, Gorham ED, Ricordi CI. There a role of vitamin D deficiency in type 1 diabetes of children? Am J Prev Med. 2010;39(2):189–90. https://doi.org/10.1016/j.amepre.2010.03.023.

    Article  PubMed  Google Scholar 

  29. Maeda SS, Borba VZC, Camargo MBR, Silva DMW, Borges JLC, Bandeira F, et al. Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D. Arq Bras Endocrinol Metab. 2014;58(5):411–33. https://doi.org/10.1590/0004-2730000003388.

    Article  Google Scholar 

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Authors and Affiliations

  1. Universidade Federal de São João Del Rei-Campus Centro-Oeste Dona Lindu, Rua Sebastião Gonçalves Coelho, 400–Chanadour, Divinópolis, MG, 35501-296, Brazil

    Vanessa Rabello Lovisi Sales de Oliveira & Caroline Pereira Domingueti

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  1. Vanessa Rabello Lovisi Sales de Oliveira
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Correspondence to Caroline Pereira Domingueti.

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Author Vanessa Rabello Lovisi Sales de Oliveira declares that she has no conflict of interest. Author Caroline Pereira Domingueti declares that she has no conflict of interest.

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de Oliveira, V.R.L.S., Domingueti, C.P. Association of vitamin D deficiency and type 1 diabetes mellitus: a systematic review and meta-analysis. Int J Diabetes Dev Ctries 38, 280–288 (2018). https://doi.org/10.1007/s13410-018-0607-4

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