Prevalence of 25-hydroxy vitamin D deficiency among type 2 diabetic subjects of South India
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Vitamin D levels have been documented to have significant inverse relationship with type 2 diabetes. However, data on the extent of vitamin D deficiency among type 2 diabetes subjects of India is lacking. The present study was undertaken among diabetic subjects of South India to address this lacuna. This retrospective study was conducted among patients attending a diabetes specialty hospital who had established type 2 diabetes mellitus. Demographic data and data on laboratory parameters such as vitamin D, HbA1c, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and serum calcium were obtained from the hospital information system. Vitamin D levels were classified as normal (≥30 ng/mL), insufficient (>20 to 29.9 ng/mL), and deficient (≤20 ng/mL). We included 4628 subjects with diabetes. Among them, 71.4 % were vitamin D deficient, 15 % were vitamin D insufficient, and 13.6 % were found to have normal vitamin D levels. On comparing the two genders, it was seen that the percentage of men and women with these conditions were similar. The proportion of subjects with these conditions across different age groups (30–50, 50–70, >70) were also similar. BMI, age, calcium levels, and HbA1c were found to be the major confounders for vitamin D status. Our study, done among type 2 diabetes people, show that vitamin D deficiency was highly prevalent among them. Considering such high prevalence, screening of diabetic patients for vitamin D deficiency would be beneficial in this population.
KeywordsSerum calcium Gender HbA1c South India Type 2 diabetes mellitus Vitamin D
We thank Mr. Sriram Ramachandran for statistical analysis and Mr. Selvakumar D, IT Department, for help in data collection.
Compliance with ethical standards
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
No funding was received for this study from any source.
Conflict of interest
The authors declare that they have no conflict of interest.
Informed consent was obtained from all individual participants included in the study.
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