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Impact of sub-gastrectomy on glucose regulation in gastric cancer patients with T2DM: a follow-up study

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Abstract

This study aims to investigate the changing characteristics of glucose regulation after gastric surgery for normal gastric cancer patients with type 2 diabetes mellitus (T2DM) (T2DM group) and without T2DM (normal group) in a tertiary hospital located in western China. We conducted a case-control study which retrospectively collected the data of 73 patients: (1) diagnosed as gastric cancer, (2) underwent sub-gastrectomy and Billroth II gastrointestinal anastomosis between October 2007 and December 2012, and (3) did not suffer a recurrent cancer and with sufficient clinical data. Fasting blood glucose (FBG), glycated hemoglobin (HbA1c), insulin sensitive index (HOMA-IS), insulin resistance index (HOMA-IR), and beta cell function index (HOMA-BCF) were compared at baseline and postoperative 7, 14, 28, 56, 120, and 356 days. Baseline FBG, HbA1c, HOMA-IS, HOMA-IR, and HOMA-BCF in the T2DM group were significantly higher than those in the normal group. Immediate postoperative glucose changed significantly, and it became stable and normal during follow-up period in both the T2DM and normal group that there was no significance anymore after postoperative 28 days between them. Normal patients with T2DM would benefit from gastric surgery in glucose control, and it may involve not only decreased food intake and weight loss but also gastrointestinal reconstruction.

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Compliance with ethical standards

Funding

This study was funded by Gansu Provincial Health Department of Research Projects (grant number WST07-07).

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Authors’ contributions

Zhang YC, Wang HL, Zhang YW, and Xu XD were involved in the study conception and design. Wei FX, Han W, and Zhang HH participated in the acquisition of data. Wei ZG, Zhang YW, Wang MC, and Xu XD were involved in the analysis and interpretation of data. Wei FX and Han W participated in the drafting of manuscript. Zhang YC and Wang HL were involved in the critical revision of manuscript.

Conflict of interest

You Cheng Zhang, Feng Xian Wei, Wei Han, Hui Lin Wang, Man Cai Wang, Ya Wu Zhang, Xiao Dong Xu, and Hui Han Zhang declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of General Surgery, Lanzhou University Second Hospital, Cuiyingmen 82, Chengguan District, Lanzhou, 730030, China

    You Cheng Zhang, Feng Xian Wei, Wei Han, Zhen Gang Wei, Hui Lin Wang, Man Cai Wang, Hui Han Zhang, Ya Wu Zhang & Xiao Dong Xu

  2. Hepato-Biliary-Pancreatic Institute, Lanzhou University Second Hospital, Lanzhou, 730030, China

    You Cheng Zhang, Feng Xian Wei, Wei Han, Zhen Gang Wei, Hui Lin Wang, Man Cai Wang, Hui Han Zhang, Ya Wu Zhang & Xiao Dong Xu

Authors
  1. You Cheng Zhang
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  2. Feng Xian Wei
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  3. Wei Han
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  4. Zhen Gang Wei
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  7. Hui Han Zhang
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  8. Ya Wu Zhang
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Corresponding author

Correspondence to You Cheng Zhang.

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Zhang, Y.C., Wei, F.X., Han, W. et al. Impact of sub-gastrectomy on glucose regulation in gastric cancer patients with T2DM: a follow-up study. Int J Diabetes Dev Ctries 36, 89–94 (2016). https://doi.org/10.1007/s13410-015-0437-6

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  • DOI: https://doi.org/10.1007/s13410-015-0437-6

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