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Effect of glycaemic control on the diurnal blood pressure variation and endogenous secretory receptor for advanced glycation end product (esRAGE) levels in type 1 diabetes mellitus

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Abstract

The relationship between plasma endogenous secretory receptor for advanced glycation end product (esRAGE) level and diurnal variation of blood pressure in type 1 diabetic patients based on their glycemic status has not yet been studied. So, the aim of the present study was to see if a correlation exists between plasma esRAGE levels and dipper status in type 1 diabetic patients based on their glycaemic status. Type 1 diabetic patients were divided as good and poor glycaemic controlled groups based on their HbA1c values. Blood glucose levels, insulin, insulin antibodies, homocysteine and esRAGE levels were determined. The hourly daytime and night-time blood pressure was monitored by using a non-invasive blood pressure (NIBP) apparatus. Of the 16 patients in the well-controlled group, most (14/16) were dippers (95 % confidence interval 1.5 to 20.7 vs. P = 0.006, Fisher’s exact test) when compared to those in the poorly controlled group (5/18). There was a significant correlation between plasma esRAGE levels and % decline in nocturnal blood pressure in both the good (r = 0.69, P = 0.003) and poorly (r = 0.79, P = 0.0002) controlled groups. Most of the poorly controlled patients showed abnormal circadian blood pressure pattern and low esRAGE level and hence were more prone to end organ damage.

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Acknowledgments

We are grateful to the participants of the study. This work was not funded by any agency.

Compliance with ethical standards

The study was approved by the Institute Research Council and Institute Human Ethics Committee. Written informed consent form was obtained from patients who agreed to participate in the study.

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Authors and Affiliations

  1. Department of Pharmacology, Mother Theresa Post Graduate and Research Institute of Health Sciences, Indira Nagar, Gorimedu, Pondicherry, 605 006, India

    R. Vimalavathini

  2. Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, 605 006, India

    B. Gitanjali

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  1. R. Vimalavathini
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  2. B. Gitanjali
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Correspondence to R. Vimalavathini.

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Vimalavathini, R., Gitanjali, B. Effect of glycaemic control on the diurnal blood pressure variation and endogenous secretory receptor for advanced glycation end product (esRAGE) levels in type 1 diabetes mellitus. Int J Diabetes Dev Ctries 37, 156–159 (2017). https://doi.org/10.1007/s13410-015-0436-7

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  • DOI: https://doi.org/10.1007/s13410-015-0436-7

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