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MicroRNAs 103 and 107 link type 2 diabetes and post-menopausal breast cancer

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Abstract

Type 2 diabetes mellitus (T2DM) increases the incidence of post-menopausal breast cancer (PMBC). This study is intended to determine whether microRNA-103/107 (miR-103/107) should be regarded as a potential molecular link between T2DM and PMBC. Samples of serum from 90 patients with T2DM and/or PMBC were collected. Samples of serum from 20 non-diabetic post-menopausal women were used as the control. The body mass index (BMI) of patients with T2DM and PMBC was lower than the BMI of patients with only T2DM or PMBC (p < 0.05). The expression of miR-103/107 was higher in the serum of T2DM patients compared with that in control samples (2.80 ± 0.46/36.29 ± 3.41 vs 0.88 ± 0.25/8.59 ± 1.91, p < 0.05). The expression of miR-103/107 in the serum of PMBC patients was higher than that in T2DM patients (5.06 ± 0.92/49.59 ± 6.99 vs 2.80 ± 0.46/36.29 ± 3.41, p < 0.05) but lower than that in patients diagnosed with both T2DM and PMBC (7.67 ± 0.87/63.24 ± 8.58, p < 0.05). miR-103/107 was positively correlated with the homeostasis model assessment-insulin resistance (HOMA-IR) index (r = 0.71, 0.685, p < 0.01). The expression of miR-103/107 was an independent factor of the HOMA-IR index (β = 0.638, 0.073, p = 0.02, 0.01). There were higher levels of estradiol (E2) in patients with T2DM and/or PMBC than that in the control group. High expression of miR-103/107 results in insulin resistance and is associated with overweight or obese patients with T2DM and PMBC through elevated levels of E2. miR-103/107 may be a potential molecular link between T2DM and PMBC.

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Acknowledgments

We thank Ye Wang (Shandong Eye Institute, No. 5 Yan’erdao Rd. Qingdao, 266071, China) for the valuable assistance.

M.Y. is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

The authors acknowledge the editorial assistance of the American Journal Experts (Durham, NC, USA) for help with preparing the manuscript.

Conflicts of interest

No potential conflicts of interest relevant to this article are reported.

Author contributions

Q.X., Y.S., and Y.L. participated in the conception and design of the study and the critical revision of the manuscript for important intellectual content. Q.X., Y.S., F.Z., S.G., and M.Y. performed the data collection and analysis. Q.X. interpreted the data and produced the draft of the manuscript. M.Y. obtained funding for the study. All authors read and approved the final version of the manuscript.

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Authors and Affiliations

  1. Department of Endocrinology, the Second Affiliated Hospital, Medical College of Qingdao University, No. 127, South Siliu Rd, Qingdao, 266042, China

    Qian Xu, Yongfang Shang, Ying Li, Fanghua Zhang, Shan Gao & Minxiu Yao

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  1. Qian Xu
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  2. Yongfang Shang
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  3. Ying Li
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Correspondence to Minxiu Yao.

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Xu, Q., Shang, Y., Li, Y. et al. MicroRNAs 103 and 107 link type 2 diabetes and post-menopausal breast cancer. Int J Diabetes Dev Ctries 36, 40–44 (2016). https://doi.org/10.1007/s13410-015-0412-2

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  • DOI: https://doi.org/10.1007/s13410-015-0412-2

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