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Association of serum ferritin concentrations with prevalence of prediabetes, type 2 diabetes mellitus, and metabolic syndrome in a Chinese population from Sichuan

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Abstract

Body iron stores reflected by serum ferritin levels have been implicated in many chronic diseases. We investigated associations between serum ferritin concentrations and the risk of prediabetes, type 2 diabetes mellitus (T2DM), and metabolic syndrome (MetS) in a Chinese population. For a cross-sectional study, 3040 subjects were recruited from three communities in Sichuan. Subjects were grouped by prediabetes or T2DM status, or components of MetS. Subjects with prediabetes were classified as having impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or both (IFG + IGT). The odds ratios, assessed by gender, for the associations between serum ferritin concentration and prediabetes, T2DM, and MetS were calculated using multivariate logistic regression. The prevalence of IGT, IFG + IGT, T2DM, and MetS in the highest quartile of ferritin concentrations was higher than those in the lowest quartile, in both genders. In women, the adjusted odds ratios of IGT, IFG + IGT, T2DM, and MetS were higher in the highest ferritin quartile than the lowest; in men, only that of IFG + IGT was higher. In both genders, high ferritin levels were associated with higher odds ratios of hypertriglyceridemia and hyperglycemia, components of MetS. IGT, IFG + IGT, T2DM, and MetS were more common in the highest ferritin quartile for both genders. Elevated ferritin concentrations were associated with an increased risk for IGT and IFG + IGT in prediabetes, T2DM, and MetS, especially in women.

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References

  1. Cook JD, Flowers CH, Skikne BS. The quantitative assessment of body iron. Blood. 2003;101:3359–64.

    Article  PubMed  CAS  Google Scholar 

  2. Galaris D, Pantopoulos K. Oxidative stress and iron homeostasis: mechanistic and health aspects. Crit Rev Clin Lab Sci. 2008;45:1–23.

    Article  PubMed  CAS  Google Scholar 

  3. Yoon JH, An SH, Kyeong IG, Lee MS, Kwon SC, Kang JH. Oxidative modification of ferritin induced by hydrogen peroxide. RMB Rep. 2011;44:165–9.

    CAS  Google Scholar 

  4. Rajpathak SN, Crandall JP, Wylie-Rosett J, Kabat GC, Rohan TE, Hu FB. The role of iron in type 2 diabetes in humans. Biochim Biophys Acta. 2009;1790:671–81.

    Article  PubMed  CAS  Google Scholar 

  5. Swaminathan S, Fonseca VA, Alam MG, Shah SV. The role of iron in diabetes and its complications. Diabetes Care. 2007;30:1926933.

    Article  Google Scholar 

  6. Fernández-Real JM, López-Bermejo A, Ricart W. Iron stores, blood donation and insulin sensitivity and secretion. Clin Chem. 2005;51:1201–5.

    Article  PubMed  Google Scholar 

  7. Kim CH, Kim HK, Bae SJ, Park JY, Lee KU. Association of elevated serum ferritin concentration with insulin resistance and impaired glucose metabolism in Korean men and women. Metabolism. 2011;60:414–20.

    Article  PubMed  CAS  Google Scholar 

  8. Sharifi F, Nasab NM, Zadeh HJ. Elevated serum ferritin concentrations in prediabetic subjects. Diab Vasc Dis Res. 2008;5:15–8.

    Article  PubMed  Google Scholar 

  9. Ren Y, Tian H, Li X, Liang J, Zhao G. Elevated serum ferritin concentrations in a glucose-impaired population and in normal glucose tolerant first-degree relatives in familial type 2 diabetic pedigrees. Diabetes Care. 2004;27:622–3.

    Article  PubMed  Google Scholar 

  10. Shi Z, Hu X, Yuan B, Pan X, Meyer HE, Holmboe-Ottesen G. Association between serum ferritin, hemoglobin, iron intake, and diabetes in adults in Jiangsu, China. Diabetes Care. 2006;29:1878–83.

    Article  PubMed  CAS  Google Scholar 

  11. Sun L, Franco OH, Hu FB, et al. Ferritin concentrations, metabolic syndrome, and type 2 diabetes in middle-aged and elderly Chinese. J Clin Endocrinol Metab. 2008;93:4690–6.

    Article  PubMed  CAS  Google Scholar 

  12. Chen T, Ren Y, Liu Y, et al. Serum gamma-glutamyl transferase, ferritin and the risk of type 2 diabetes in women from a Chinese minority. Diabetes Res Clin Pract. 2010;90:352–7.

    Article  PubMed  CAS  Google Scholar 

  13. Jehn M, Clark JM, Guallar E. Serum ferritin and risk of the metabolic syndrome in U.S. adults. Diabetes Care. 2004;27:2422–8.

    Article  PubMed  Google Scholar 

  14. Vari IS, Balkau B, Kettaneh A, et al. Ferritin and transferrin are associated with metabolic syndrome abnormalities and their change over time in a general population: data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR). Diabetes Care. 2007;30:1795–801.

    Article  PubMed  CAS  Google Scholar 

  15. Lee BK, Kim Y, Kim YI. Association of serum ferritin with metabolic syndrome and diabetes mellitus in the South Korean general population according to the Korean National Health and Nutrition Examination Survey 2008. Metabolism. 2011;60:1416–24.

    Article  PubMed  CAS  Google Scholar 

  16. Yoo KD, Ko SH, Park JE, et al. High serum ferritin levels are associated with metabolic risk factors in non-obese Korean young adults: Korean National Health and Nutrition Examination Survey (KNHANED) IV. Clin Endocrinol. 2012;77:233–40.

    Article  CAS  Google Scholar 

  17. Kang HT, Linton JA, Shim JY. Serum ferritin level is associated with the prevalence of metabolic syndrome in Korean adults: the 2007-2008 Korean National Health and Nutrition Examination Survey. Clin Chim Acta. 2012;413:636–41.

    Article  PubMed  CAS  Google Scholar 

  18. Otani H. Oxidative stress as pathogenesis of cardiovascular risk associated with metabolic syndrome. Antioxid Redox Signal. 2011;15:1911–26.

    Article  PubMed  CAS  Google Scholar 

  19. Yang W, Lu J, Weng J, et al. China National Diabetes and Metabolic Disorders Study Group. Prevalence of diabetes among men and women in China. N Engl J Med. 2010;362:1090–101.

    Article  PubMed  CAS  Google Scholar 

  20. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2008;31:S55–60.

    Article  Google Scholar 

  21. Zimmet P, Magliano D, Matsuzawa Y, Alberti G, Shaw J. The metabolic syndrome: a global public health problem and a new definition. J Atheroscler Thromb. 2005;12:295–300.

    Article  PubMed  CAS  Google Scholar 

  22. Nilsen V, Bakke PS, Gallefoss F. Effects of lifestyle intervention in persons at risk for type 2 diabetes mellitus-results from a randomised, controlled trial. BMC Public Health. 2011;11:893.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Unwin N, Shaw J, Zimmet P, Alberti KG. Impaired glucose and impaired fasting glycaemia: the current status on definition and intervention. Diabet Med. 2002;19:708–23.

    Article  PubMed  CAS  Google Scholar 

  24. He Y, Ma G, Zhai F, et al. Dietary patterns and glucose tolerance abnormalities in Chinese adults. Diabetes Care. 2009;32:1972–6.

    Article  PubMed  PubMed Central  Google Scholar 

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Funding

This study was supported by grants from the Chinese Medical Association Foundation and Chinese Diabetes Society.

Conflict of interest

None declared.

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Authors and Affiliations

  1. Division of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, 610041, China

    Yuanyuan Liu, Jie Song, Haoming Tian, Tao Chen, Yun Gao & Yan Ren

  2. Laboratory of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, 610041, China

    Honglin Yu & Xiangxun Zhang

Authors
  1. Yuanyuan Liu
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  2. Jie Song
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  3. Haoming Tian
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  4. Tao Chen
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  5. Yun Gao
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  6. Honglin Yu
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  7. Xiangxun Zhang
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  8. Yan Ren
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Correspondence to Yan Ren.

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Liu, Y., Song, J., Tian, H. et al. Association of serum ferritin concentrations with prevalence of prediabetes, type 2 diabetes mellitus, and metabolic syndrome in a Chinese population from Sichuan. Int J Diabetes Dev Ctries 35 (Suppl 3), 522–528 (2015). https://doi.org/10.1007/s13410-015-0308-1

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  • DOI: https://doi.org/10.1007/s13410-015-0308-1

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