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Carotid IMT in young adult offspring of diabetic and/or hypertensives

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Abstract

Atherosclerosis begins in childhood and progresses through young adulthood to form the lesions that cause coronary heart disease. These preclinical lesions are associated with coronary heart disease risk factors in young persons. Intima-media thickness is a well-known marker of subclinical atherosclerosis and it also can indicate future cardio-cerebrovascular disease and is a noninvasive, feasible, reliable, and inexpensive method for detecting development of subclinical atherosclerosis. This study sought to determine whether family history of diabetes and hypertension are associated with carotid intima-media thickness (cIMT) in adolescents. Carotid intima-media thicknesses were measured by B-mode ultrasonography in 203 adolescents (18 to 25 years). The effects of family history of diabetes and hypertension, sex, age, body mass index, cholesterol, and blood pressure were studied. The mean values of cIMT were 0.489 mm in both study group and controls. In adolescents, higher cIMT was associated with diabetic father, over weight (BMI > 23.5 kg/m2) and male sex. Higher cIMT is associated with diabetic father, over weight (BMI > 23.5 kg/m2), and male sex. Using cIMT in young adults with family history of diabetes and hypertension alone may not be useful screening tool for detection of atherosclerosis.

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Abbreviations

cIMT:

Carotid intima-media thickness

BMI:

Body mass index

HbA1C:

Glycosylated hemoglobin

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Acknowledgments

We thank Dr. Lancy for statistical programming assistance. We are especially indebted to the study participants who were our medical under graduate students. We thank JSS Medical College & Hospital for their kind support for our study.

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Authors and Affiliations

  1. Department of Medicine and Radiology, JSS Medical College & Hospital, Mysore, India

    N. Vijay Cheluvaraj, K. A. Sudharshana Murthy, Shetty Chandrashekar, H. S. Kiran, M. J. Geetha & J. Tejaswini.

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  1. N. Vijay Cheluvaraj
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  2. K. A. Sudharshana Murthy
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  3. Shetty Chandrashekar
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  4. H. S. Kiran
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  5. M. J. Geetha
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  6. J. Tejaswini.
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Corresponding author

Correspondence to N. Vijay Cheluvaraj.

Additional information

Our study received financial support from RSSDI, Karnataka Chapter.

Our study was performed after approval from JSS University Ethical Committee.

Written consent was taken from all the study participants.

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Cheluvaraj, N.V., Sudharshana Murthy, K.A., Chandrashekar, S. et al. Carotid IMT in young adult offspring of diabetic and/or hypertensives. Int J Diabetes Dev Ctries 35, 280–284 (2015). https://doi.org/10.1007/s13410-014-0260-5

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  • DOI: https://doi.org/10.1007/s13410-014-0260-5

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