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Oxidant and antioxidant parameters in prediabetes and diabetes

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Abstract

The aim of our study was to evaluate serum paraoxonase (PON1), total antioxidant status (TAS), total oxidant status (TOS), and ischemia-modified albumin (IMA) levels in patients with prediabetes, diabetes, and in healthy control subjects. The subjects were aged between 20 and 60 years. Forty diabetic subjects (mean age 46.6 ± 9.7 years), 39 prediabetic subjects (mean age 44.0 ± 9.3 years) and 24 healthy control subjects (mean age 43.7 ± 9.7 years). Lipid profile, PON1, TAS, TOS and IMA levels were measured. The serum TOS and IMA levels in diabetes were significantly higher than those of the control subjects (P = 0.024 and P = 0.012, respectively), while the serum PON1 levels of the diabetes patients were significantly lower than those of the control subjects (P = 0.039). The serum TOS levels of the diabetes patients were significantly higher than those of the subjects with prediabetes (P = 0.013). There were no significant differences between the serum IMA and PON1 levels of the prediabetes and diabetes groups (P = 0.075 and P = 0.110, respectively). The serum TAS levels of the three groups were similar. The present study demonstrated that in diabetes there is greater oxidative stress. Patients with type 2 diabetes had higher TOS and IMA levels, but lower PON1 values, than controls. There were no differences in oxidative stress markers between prediabetic patients and healthy subjects.

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Acknowledgments

Financial support of the present study was provided by the Scientific Investigation and Project Foundation of Selcuk University.

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Authors and Affiliations

  1. Department of Biochemistry, Konya Training and Research Hospital, Konya, Turkey

    Said Sami Erdem

  2. Department of Biochemistry, Necmettin Erbakan University, Meram Faculty of Medicine, Konya, Turkey

    Aysun Toker, Hümeyra Çiçekler & Fatma Hümeyra Yerlikaya

  3. Department of Cardiology, Necmettin Erbakan University, Meram Faculty of Medicine, Konya, Turkey

    Mehmet Kayrak & Turyan Abdulhalikov

  4. Department of Internal Medicine, Division of Endocrinology, Necmettin Erbakan University, Meram Faculty of Medicine, Konya, Turkey

    Gülsüm Gönülalan & Ahmet Kaya

  5. Konya Eğitim ve Araştırma Hastanesi Biyokimya Laboratuvarı, 42040, Konya, Turkey

    Said Sami Erdem

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  1. Said Sami Erdem
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Correspondence to Said Sami Erdem.

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The Authors state that this manuscript has not been published previously and is not currently being assessed for publication by any journal other than the ‘International Journal of Diabetes in Developing Countries’.

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Erdem, S.S., Toker, A., Kayrak, M. et al. Oxidant and antioxidant parameters in prediabetes and diabetes. Int J Diabetes Dev Ctries 35 (Suppl 3), 465–470 (2015). https://doi.org/10.1007/s13410-013-0185-4

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  • DOI: https://doi.org/10.1007/s13410-013-0185-4

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