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The association between diabetes mellitus and Helicobacter pylori infection

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Abstract

Helicobacter pylori is a major cause of duodenal and gastric diseases. The aim of this study was to estimate the prevalence of H. pylori infection in patients with diabetes mellitus, and to investigate the association between H. pylori infection and upper gastrointestinal symptoms. In this case-control study, 79 diabetic patients and 84 control subjects with upper gastrointestinal symptoms were included. Upper gastrointestinal endoscopy was performed and gastric mucosa biopsied. H. pylori was identified by rapid urease test and by histology. A serum sample was obtained to measure H. pylori antibodies. The adjusted odds ratio estimates of H. pylori infection among pre-diabetic and diabetic subjects compared to non-diabetic subjects were 0.51 (95 % CI: 0.16, 1.63) and 1.33 (95 % CI: 0.64, 1.79) respectively. No association was found between H. pylori infection and upper gastrointestinal symptoms among three groups. The serology test for H. pylori was positive in 54.4 % (43) of diabetics and 61.4 % (43) of non-diabetic patients (P = 0.689, non-significant). There was significant difference in rapid urease test between diabetes mellitus patients and non-diabetes patients (70.9 % versus 48.6 %, P = 0.002). There was no association between upper gastrointestinal symptoms among diabetes mellitus, pre-diabetic and non-diabetic patients. We found no association between H. pylori infection and diabetes mellitus.

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Acknowledgments

The authors thank Mrs. Narges Jafarzadeh for help in collection of data and Mr. Khosrow Mani Kashani for assistance in statistical analysis. This study was supported by the Vice-Chancellor of Research and Technology, Hamadan University of Medical sciences, Hamadan, Iran.

Conflict of interest

None declared

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Authors and Affiliations

  1. Department of Infectious Diseases, Hamadan University of Medical Sciences, Hamadan, Iran

    Fariba Keramat & Seyyed Hamid Hashemi

  2. Division of Gastroenterology, Department of Internal Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

    Amir Majlesi

  3. Division of Endocrinology, Department of Internal Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

    Shahram Haddadinejad

  4. Department of Pathology, Hamadan University of Medical Sciences, Hamadan, Iran

    Alireza Monsef Esfehani

  5. Research Center for Health Sciences and Department of Epidemiology & Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran

    Jalal Poorolajal

  6. Division of Infectious Diseases, Mirzadeh-Eshghi Street, Sina Hospital, Hamadan, 65168, Iran

    Seyyed Hamid Hashemi

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  1. Fariba Keramat
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  2. Seyyed Hamid Hashemi
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  3. Amir Majlesi
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  4. Shahram Haddadinejad
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  5. Alireza Monsef Esfehani
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Correspondence to Seyyed Hamid Hashemi.

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Keramat, F., Hashemi, S.H., Majlesi, A. et al. The association between diabetes mellitus and Helicobacter pylori infection. Int J Diabetes Dev Ctries 33, 155–160 (2013). https://doi.org/10.1007/s13410-013-0128-0

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  • DOI: https://doi.org/10.1007/s13410-013-0128-0

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