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Unusual selectivity in gold-catalyzed intermolecular Heck reactions

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Abstract

The Heck reaction has been considered a robust method for the cross-coupling reaction of olefins and aryl halides to yield alkenes. However, the most significant requirement is the necessity of electronically biased olefins and the requirement of directing group to control the regioselectivity of the Heck reaction. The research group of Patil and Gandon recently documented the gold-catalyzed Heck reaction, demonstrating the utilization of simple aliphatic alkenes as substrates. This approach does not need electronically biased olefins and offers a distinct regioselectivity when compared to the Heck reaction catalyzed by other transition metal catalysts.

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Acknowledgements

MBT thanks SERB, New Delhi, for providing a postdoctoral fellowship (PDF/2022/002920)

Funding

Generous financial support by the Science and Engineering Research Board (SERB), New Delhi (CRG/2022/000195, SCP/2022/000063, and JCB/2022/000052), is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhauri, Bhopal, 462 066, India

    Mahesh Bhagwan Thoke & Nitin T. Patil

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  1. Mahesh Bhagwan Thoke
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  2. Nitin T. Patil
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M. B. T. wrote the manuscript. N.T.P. proofread and endorsed the content.

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Correspondence to Nitin T. Patil.

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Thoke, M.B., Patil, N.T. Unusual selectivity in gold-catalyzed intermolecular Heck reactions. Gold Bull 56, 159–165 (2023). https://doi.org/10.1007/s13404-024-00342-w

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