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The potential of marine-based gold nanomaterials in cancer therapy: a mini-review

Gold Bulletin volume 55, pages 53–63 (2022)Cite this article

Abstract

Cancer is still one of the most common causes of death today despite advances in its detection and treatment. The present article reviews the application of marine-based gold nanoparticles in the diagnosis and treatment of cancer. The main data were collected from original research articles on the application of different marine-based gold nanoparticles in detecting and imaging cancer cells as well as in drug delivery systems and treatment of cancer. The results show the excellent anticancer potential of both gold nanoparticles and natural marine products. The most studied marine-based gold nanomaterial was chitosan-based ones, in which the role of chitosan is a stabilizer not an anticancer agent. Despite the excellent anticancer potential of different marine natural products, limited studies have been conducted using gold nanoparticles in their composition in cancer therapy. Moreover, most of these studies are related to their application as a drug delivery system not an anticancer drug. Although there are serious challenges in the application of nanoparticles in medicine, marine-based gold nanomaterials may promise an interesting novel strategy in the oncology field.

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Funding

The authors received financial support from Iran’s National Elites Foundation (INEF) under program of “Allame Tabatabaei Post-Doc Fellowship.” The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Authors and Affiliations

  1. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran

    Neda Baghban, Arezoo Khoradmehr, Iraj Nabipour & Amin Tamadon

  2. Institute for Immunity and Transplantation, Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Palo Alto, CA, 94304, USA

    Mujib Ullah

  3. Department of Genomics and Cellular Biology, Genentech (Member of Roche Group) Inc, South San Francisco, CA, 94080, USA

    Mujib Ullah

Authors
  1. Neda Baghban
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  2. Arezoo Khoradmehr
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  3. Iraj Nabipour
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  4. Amin Tamadon
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  5. Mujib Ullah
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Contributions

Conceptualization: N.B. and A.T.; methodology: N.B. and A.T.; investigation: N.B. and A.K.; writing—original draft preparation: N.B.; writing—review and editing: A.K., I.N., M.U., and A.T.; supervision: I.N., M.U., and A.T.; project administration: I.N. and A.T.; funding acquisition,: I.N. and N.B. All authors have read and agreed to the published version of the manuscript.

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Correspondence to Iraj Nabipour, Amin Tamadon or Mujib Ullah.

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Baghban, N., Khoradmehr, A., Nabipour, I. et al. The potential of marine-based gold nanomaterials in cancer therapy: a mini-review. Gold Bull 55, 53–63 (2022). https://doi.org/10.1007/s13404-021-00304-6

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  • DOI: https://doi.org/10.1007/s13404-021-00304-6

Keywords

  • Gold nanoparticles
  • Marine
  • Drug delivery
  • Imaging
  • Cancer
  • Detection