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Ferritinophagy induced ferroptosis in the management of cancer

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Abstract

Background

Ferroptosis, a newly form of regulated cell death (RCD), is characterized by iron dyshomeostasis and unrestricted lipid peroxidation. Emerging evidence depicts a pivotal role for ferroptosis in driving some pathological processes, especially in cancer. Triggering ferroptosis can suppress tumor growth and induce an anti-tumor immune response, denoting the therapeutic promises for targeting ferroptosis in the management of cancer. As an autophagic phenomenon, ferritinophagy is critical to induce ferroptosis by degradation of ferritin to release intracellular free iron. Recently, a great deal of effort has gone into designing and developing anti-cancer strategies based on targeting ferritinophagy to induce ferroptosis.

Conclusion

This review delineates the regulatory mechanism of ferritinophagy firstly and summarizes the role of ferritinophagy-induced ferroptosis in cancer. Moreover, the strategies targeting ferritinophagy to induce ferroptosis are highlighted to unveil the therapeutic value of ferritinophagy as a target to manage cancer. Finally, the future research directions on how to cope with the challenges in developing ferritinophagy promoters into clinical therapeutics are discussed.

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Acknowledgements

This work was supported by National Natural Science Foundation of China (No. 82274153 and 82173846), Young Talent Lifting Project of China Association of Chinese Medicine [No. CACM-(2021-QNRC2-A08)], Shanghai Rising-Star Program (No.22QA1409100), 2021 Shanghai Science and Technology Innovation Action Plan (No. 21S11902800), Three-year Action Plan for Shanghai TCM Development and Inheritance Program [ZY(2021-2023)-0401, ZY(2021-2023)-0208], Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (No. ZYYCXTD-D-202004), and Innovation team of high-level local universities in Shanghai: Strategic Innovation Team of TCM Chemical Biology.

The figures were created with BioRender software (BioRender.com).

Funding

This work was supported by National Natural Science Foundation of China (No. 82274153 and 82173846), Oriental Scholars of Shanghai Universities (TP2022081), Jiangxi Province Thousand Talents Program (jxsq2023102168), Young Talent Lifting Project of China Association of Chinese Medicine [No. CACM-(2021-QNRC2-A08)], Shanghai Rising-Star Program (No.22QA1409100), 2021 Shanghai Science and Technology Innovation Action Plan (No. 21S11902800), Three-year Action Plan for Shanghai TCM Development and Inheritance Program [ZY(2021–2023)-0401, ZY(2021–2023)-0208], Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (No. ZYYCXTD-D-202004), and Innovation team of high-level local universities in Shanghai: Strategic Innovation Team of TCM Chemical Biology.

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  1. Yi-Chen Liu and Yi-Ting Gong contributed equally to this work.

Authors and Affiliations

  1. Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China

    Yi-Chen Liu, Yi-Ting Gong, Bei Wang, Yue Yan, Yi-Xu Chen, Li-Jun Zhang, Wei-Dong Zhang & Xin Luan

  2. Shanghai Institute of Pharmaceutical Industry, Shanghai, 200040, China

    Qing-Yan Sun

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Yi-Chen Liu and Yi-Ting Gong: wrote the draft manuscript. Qing-Yan Sun, Bei Wang, Yue Yan, and Yi-Xu Chen: helped with analysis and literature review. Li-Jun Zhang, Wei-Dong Zhang, and Xin Luan: designed and revised the manuscript. All authors read and approved the final version of the manuscript.

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Liu, YC., Gong, YT., Sun, QY. et al. Ferritinophagy induced ferroptosis in the management of cancer. Cell Oncol. 47, 19–35 (2024). https://doi.org/10.1007/s13402-023-00858-x

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