Cellular Oncology

, Volume 40, Issue 2, pp 105–118 | Cite as

Emerging diagnostic, prognostic and therapeutic biomarkers for ovarian cancer

  • Khalid El BairiEmail author
  • Abdul Hafeez Kandhro
  • Adel Gouri
  • Wafaa Mahfoud
  • Noureddine Louanjli
  • Brahim Saadani
  • Said Afqir
  • Mariam Amrani



In spite of various treatment options currently available, ovarian cancer (OC) still remains a leading cause of death in women world-wide. Diagnosis at an early stage is one of the most important factors that determines survival. Current clinical diagnostic tools have, however, a limited efficacy in early OC detection. Therefore, there is a critical need for new (early) diagnostic biomarkers and tools. Through advances in genomic, proteomic and metabolomic techniques, several novel molecular OC biomarkers have recently been identified. These biomarkers are currently subject to validation. In addition, integration of genomic, proteomic and metabolomic data, in conjunction with epidemiologic and clinical data, is considered essential for obtaining useful results. Interesting recent work has already shown that specific diagnostic biomarkers, such as BRCA mutations, may have profound therapeutic implications. Here, we review the current state of OC research through literature and database searches, with a focus on various recently identified biomarkers via different technologies for the (early) diagnosis, prognosis and treatment of OC.


Multi-biomarker panels accompanied by a meticulous determination of their sensitivity and specificity, as well their validation, using multivariate analyses will be critical for its clinical application, including early OC detection and tailor-made OC treatment.


Ovarian cancer Biomarkers Diagnosis Prognosis Circulating tumor cells Epigenetics 



We are grateful to Pr. Fourtassi Maryam, associate professor of physical medicine and rehabilitation at the Medical School of Oujda-Morocco, for her constant encouragement and to Pr. SELLAM Amar for revising the English of the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.

Supplementary material

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Supplementary Figure 1 (DOCX 69 kb)
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Supplementary Figure 5 (DOCX 65 kb)
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Supplementary Table 1 (DOCX 12 kb)
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Supplementary Table 2 (DOCX 16 kb)
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Supplementary Table 3 (DOCX 13 kb)
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Supplementary Table 4 (DOCX 13 kb)


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Copyright information

© International Society for Cellular Oncology 2016

Authors and Affiliations

  • Khalid El Bairi
    • 1
    • 2
    Email author
  • Abdul Hafeez Kandhro
    • 3
  • Adel Gouri
    • 4
  • Wafaa Mahfoud
    • 5
  • Noureddine Louanjli
    • 6
  • Brahim Saadani
    • 7
  • Said Afqir
    • 8
  • Mariam Amrani
    • 9
  1. 1.Faculty of Medicine and PharmacyOujdaMorocco
  2. 2.Independent Research Team in Cancer Biology and Bioactive CompoundsMohammed 1st UniversityOujdaMorocco
  3. 3.Department of BiochemistryHealthcare Molecular and Diagnostic LaboratoryHyderabadPakistan
  4. 4.Laboratory of Medical BiochemistryIbn Rochd University HospitalAnnabaAlgeria
  5. 5.Laboratory of Biology and Health, URAC-34, Faculty of Science Ben MsikUniversity Hassan II, MohammediaCasablancaMorocco
  6. 6.Labomac IVF Centers and Clinical Laboratory MedicineCasablancaMorocco
  7. 7.IVF center IRIFIVClinique des IrisCasablancaMorocco
  8. 8.Department of Medical OncologyMohamed 1st University HospitalOujdaMorocco
  9. 9.Equipe de Recherche ONCOGYMA, Faculty of Medicine, Pathology Department, National Institute of OncologyUniversité Mohamed VRabatMorocco

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