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Long non-coding RNAs in cancer: implications for personalized therapy

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An Erratum to this article was published on 07 October 2014

Abstract

Long non-coding RNAs (lncRNAs, pseudogenes and circRNAs) have recently come into light as powerful players in cancer pathogenesis and it is becoming increasingly clear that they have the potential of greatly contributing to the spread and success of personalized cancer medicine. In this concise review, we briefly introduce these three classes of long non-coding RNAs. We then discuss their applications as diagnostic and prognostic biomarkers. Finally, we describe their appeal as targets and as drugs, while pointing out the limitations that still lie ahead of their definitive entry into clinical practice.

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Acknowledgments

The authors apologize to all colleagues whose work could not be cited owing to space restrictions. We thank S. Lubrano for helping with figures. Funding: This work is supported by start-up funds awarded by Istituto Toscano Tumori to L.P. The authors declare no competing financial interests.

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  1. Oncogenomics Unit, Core Research Laboratory, Istituto Toscano Tumori c/o IFC-CNR, via Moruzzi 1, 56124, Pisa, Italy

    Marianna Vitiello, Andrea Tuccoli & Laura Poliseno

  2. Institute of Clinical Physiology, National Research Council, Pisa, Italy

    Laura Poliseno

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  1. Marianna Vitiello
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  2. Andrea Tuccoli
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Correspondence to Laura Poliseno.

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After our manuscript was accepted for publication, Han and colleagues (Han et al., Nature Communications 2014, PMID: 24999802) have reported the analysis of the pseudogene expression profile of almost three thousand patients samples belonging to seven different cancer types. This comprehensive study strengthens the power of pseudogenes as diagnostic and prognostic biomarkers.

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Vitiello, M., Tuccoli, A. & Poliseno, L. Long non-coding RNAs in cancer: implications for personalized therapy. Cell Oncol. 38, 17–28 (2015). https://doi.org/10.1007/s13402-014-0180-x

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