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Preliminary screening on anticandidal properties of marine macroalgae collected from Palk Bay and Gulf of Mannar, southeast coast of India


Macroalgal extracts contain a wide range of bioactive compounds; due to its naturally acquiring compounds, macroalgae has been used in the pharmacological field to cure various diseases. In this study, totally 23 species of macroalgae were collected from Palk bay and Gulf of Mannar regions comprising 9 species of Chlorophyta, 7 species of Phaeophyta, and 7 species of Rhodophyta. The anticandidal properties of the collected macroalgae were studied using various solvents against five different Candida strains. The well-diffusion method has been carried out to study the activity of macroalgal extract. Zone of inhibition was recorded as high in acetone extract followed by methanol, ethyl acetate, hexane, aqueous, and dimethyl sulfoxide. The result shows that the division Rhodophyta exhibits highest anticandidal property followed by Phaeophyta, and Chlorophyta. The acetone, methanol, ethyl acetate and hexane extracts obtained from P. hornemannii, S. robusta, G. Acerosa (red macroalgae), T. ornata, S. cinereum, and L. Variegata (brown macroalgae), and U. lactuca, C. vagabunda, and C. decorticatum (green macroalgae) exhibit activity against most of the tested Candida spp. Halimeda opuntia, Caulerpa peltata, Halimeda macroloba, Chaetomorpha aerea, and Turbinaria decurrens do not exhibit inhibitory activity against any of the tested Candida strains. The main objective of the study is to screen various microalgal extracts that exhibit anticandidal activity and to find the drugs with anticandidal potential.

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Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.


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The authors thank the authorities of Bharathidasan University for the facility provided. Thanks are due to Mr. P. Emmanuel Charles for proof reading and check the plagiarism of the article.

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KarupannaGounderRajan Priyanka: Sample collection, investigation, method standardization, and writing—original draft. Rajendran Rajaram: investigation, conceptualization, writing – review and editing, and supervision.

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Correspondence to R. Rajaram.

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• In total, 23 species of macroalgae were collected from Palk bay and Gulf of Mannar.

• Six different macroalgal extracts were used against Candidal strains to assess the anticandidal activity.

• Anticandidal activity recorded in Rhodophyta was higher than Phaeophyta and Chlorophyta.

• Activity of extracts in order of solvents is acetone > methanol > ethyl acetate > hexane > aqueous > DMSO.

U. lactuca, T. ornata, P. hornemannii, and S. robusta exhibit activity against most of the tested Candida spp.

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Priyanka, K.R., Rajaram, R. Preliminary screening on anticandidal properties of marine macroalgae collected from Palk Bay and Gulf of Mannar, southeast coast of India. Biomass Conv. Bioref. (2022).

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