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Chiliadenus sericeus subsp. virescens (Maire) Greuter: Phytochemical Assessments, Antimicrobial, Free Radical Scavenging, Antidiabetic, and Antiproliferative Properties

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Abstract

Various Chiliadenus species are extensively dispersed in Palestine and were used in ancient medicine to cure a variety of illnesses. In this regard, the goal of the present study was to characterize Chiliadenus sericeus subsp. virescens (CVS) lipophilic and hydrophilic extracts phytoconstituents and estimate their antimicrobial, antioxidant, antidiabetic, and antiproliferative capabilities. The chemical assessments were determined using standard analytical techniques. The CVS extracts antimicrobial characteristics were estimated using the microdilution method against seven microbial species. Diphenylpicrylhydrazine (DPPH) free radical and α-amylase inhibitory assays were used to assess the extract's antioxidant and antidiabetic capabilities. Furthermore, the MTT colorimetric approach was used to evaluate cell viability and proliferation in different cell lines. The hydrophilic extract suppressed the growth of Methicillin-resistant Staphylococcus aureus (MRSA) strains, making it even more effective than the antibiotic ciprofloxacin. In the case of Staphylococcus aureus, CSV hydrophilic extract at a dose of 2 mg/ml has more potent activity than ampicillin at the same dose. In addition, it has the same inhibitory effect as Fluconazole against Candida albicans. Moreover, compared to Trolox, the hydrophilic extract demonstrated significant antioxidant activity with an IC50 of 15.13 ± 0.72 μg/ml. In addition, the lipophilic extract demonstrated remarkable α-amylase enzyme inhibitory action compared to acarbose. Finally, the lipophilic extract shows cytotoxic effects on all cancer cells examined. Our findings suggest that CSV lipophilic and hydrophilic extracts might be a potential synthetic drugs alternative treatment for oxidative stress-induced illnesses, diabetes, microbial infections, and cancer.

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All the utilized data to support the findings of the current study are included in the article.

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Acknowledgements

The authors would like to acknowledge the Faculty of Medicine and Health Sciences at An-Najah National University for facilitating the accomplishment of the current study.

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Authors and Affiliations

  1. Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus, Palestine

    Malik Alqub, Mohammad Qadi, Nihad Al-Othman & Abdulraziq Zarour

  2. Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus, Palestine

    Nidal Jaradat, Mohammed Hawash, Amal Bani Fadel, Hend Bsharat, Lama Tabooq, Marah Bani Fadel, Fatima Hussein & Linda Issa

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  1. Malik Alqub
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Contributions

NJ and MA designed the study. All authors performed the experiments. NJ and MA wrote the manuscript. All authors analyzed the data, interpreted the data, and drafted and edited the manuscript. All authors read and approved the final draft.

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Correspondence to Malik Alqub or Nidal Jaradat.

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Alqub, M., Jaradat, N., Hawash, M. et al. Chiliadenus sericeus subsp. virescens (Maire) Greuter: Phytochemical Assessments, Antimicrobial, Free Radical Scavenging, Antidiabetic, and Antiproliferative Properties. Arab J Sci Eng 48, 7305–7314 (2023). https://doi.org/10.1007/s13369-022-07515-9

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