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The Application of Clay-Based Nanocomposite Hydrogels in Wound Healing

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Abstract

Recently, nanoclays have gained amount of attention as being the potential nanomaterials in the wound healing field. Due to having a high specific area, high adsorption of several therapeutic agents, good chemical inertness, and low cost, these nanomaterials are more interested in using. In this paper, we thoroughly introduced common types of nanoclays such as halloysite, kaolinite, montmorillonite, and bentonite. Interesting physical and chemical characteristics of these nanoclays are described. Further, the methods through which nanoclays are processed to form hydrogels are described. These included methods are not limited to in situ free radical polymerization, supramolecular assembly, freeze-thawing, and grafting. Finally, in this paper clay-based hydrogels and their unique properties such as antimicrobial properties and their application in wound healing are thoroughly discussed.

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Authors and Affiliations

  1. Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

    Zahra Rezanejad Gatabi

  2. College of Pharmacy, University of Texas, Austin, USA

    Niloofar Heshmati

  3. Amol Faculty of Paramedical Sciences, Mazandaran University of Medical Sciences, Sari, Iran

    Mehri Mirhoseini

  4. Department of Engineering Technology, Texas State University, San Marcos, TX, USA

    Maedeh Dabbaghianamiri

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  1. Zahra Rezanejad Gatabi
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  2. Niloofar Heshmati
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  3. Mehri Mirhoseini
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  4. Maedeh Dabbaghianamiri
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Correspondence to Maedeh Dabbaghianamiri.

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Rezanejad Gatabi, Z., Heshmati, N., Mirhoseini, M. et al. The Application of Clay-Based Nanocomposite Hydrogels in Wound Healing. Arab J Sci Eng 48, 8481–8494 (2023). https://doi.org/10.1007/s13369-022-06959-3

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  • DOI: https://doi.org/10.1007/s13369-022-06959-3

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