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Synthesis, Structural and Biological Studies of Organotin(IV) Complexes with N-(Dithiocarboxy) Sarcosine

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Abstract

Five organotin complexes with general formulae [LCSSSnR2]n (R = Me, n-Bu, Ph) and R3SnLCSSSnR3 (R = n-Bu, Ph) were synthesized by the reaction of equimolar quantities of sarcosine (HLH) with KOH, CS2 and either R2SnCl2 (R = Me, n-Bu, Ph) or R3SnCl (R = n-Bu, Ph) in methanol. Elemental (CHNS) analyses data and mass spectroscopy agreed well with the molecular composition of the synthesized products. FTIR spectroscopy verified the monodentate binding mode of the carboxylate group and a bidentate chelating behavior of the dithiocarboxylate moiety of the ligand for binding with tin(IV). Thus, penta- and hexa-coordinated environments around tin were observed in the solid state in di- and triorganotin complexes, respectively. The penta-coordinated geometry in diorganotin(IV) product 2 was further verified by its single-crystal XRD analysis. The organotin moieties and ligand units were interconnected with each other alternately in hexameric cyclic arrangement. The number of protons found in 1H NMR spectra was in good agreement with those calculated by incremental method. Complexes were examined for their antioxidant, antimicrobial, antidiabetic, thrombolytic, hemolytic activities. The free ligand HLH was found inactive against all the four bacterial strains.

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Authors and Affiliations

  1. Department of Chemistry, Lahore Garrison University, DHA Phase VI, Lahore, Pakistan

    Shabbir Hussain

  2. Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan

    Saqib Ali & Saira Shahzadi

  3. Department of Chemistry, University of Sargodha, Sargodha, 40100, Pakistan

    Muhammad Riaz & Khalida Nazir

  4. Department of Chemistry, University of Sargodha, Women Campus Faisalabad, Faisalabad, Pakistan

    Muhammad Riaz & Khalida Nazir

  5. Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, 21589, P.O. Box 80203, Saudi Arabia

    Muhammad Nadeem Arshad & Abdullah M. Asiri

  6. Center of Excellence for Advanced Materials Research (CEAMR), Faculty of Science, King Abdulaziz University, Jeddah, 21589, P.O. Box 80203, Saudi Arabia

    Muhammad Nadeem Arshad & Abdullah M. Asiri

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  1. Shabbir Hussain
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  2. Saqib Ali
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  3. Saira Shahzadi
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  4. Muhammad Riaz
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Correspondence to Shabbir Hussain, Saqib Ali or Saira Shahzadi.

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Hussain, S., Ali, S., Shahzadi, S. et al. Synthesis, Structural and Biological Studies of Organotin(IV) Complexes with N-(Dithiocarboxy) Sarcosine. Arab J Sci Eng 45, 4785–4795 (2020). https://doi.org/10.1007/s13369-020-04496-5

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  • DOI: https://doi.org/10.1007/s13369-020-04496-5

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