Skip to main content

Advertisement

SpringerLink
Log in

S100B and its association with HIV-associated neurocognitive disorders

  • Letter to the Editor
  • Published:
Journal of NeuroVirology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abbreviations

ART:

antiretroviral therapy

CSF:

cerebrospinal fluid

HAND:

HIV-associated neurocognitive disorders

HIV:

human immunodeficiency virus

IQR:

interquartile range

sRAGE:

soluble form of advanced glycation end product receptor

S100B:

S100 calcium-binding protein B

References

  • Abassi M, Morawski BM, Nakigozi G, Nakasujja N, Kong X, Meya DB, Robertson K, Gray R, Wawer MJ, Sacktor N, Boulware DR (2017) Cerebrospinal fluid biomarkers and HIV-associated neurocognitive disorders in HIV-infected individuals in Rakai, Uganda. J Neuro-Oncol 23:369–375

    CAS  Google Scholar 

  • Antinori A, Arendt G, Becker JT, Brew BJ, Byrd DA, Cherner M, Clifford DB, Cinque P, Epstein LG, Goodkin K, Gisslen M, Grant I, Heaton RK, Joseph J, Marder K, Marra CM, McArthur JC, Nunn M, Price RW, Pulliam L, Robertson KR, Sacktor N, Valcour V, Wojna VE (2007) Updated research nosology for HIV-associated neurocognitive disorders. Neurology 69:1789–1799

    Article  CAS  Google Scholar 

  • Kallianpur KJ, Gerschenson M, Mitchell BI, LiButti DE, Umaki TM, Ndhlovu LC, Nakamoto BK, Chow DC, Shikuma CM (2016a) Oxidative mitochondrial DNA damage in peripheral blood mononuclear cells is associated with reduced volumes of hippocampus and subcortical gray matter in chronically HIV-infected patients. Mitochondrion 28:8–15

    Article  CAS  Google Scholar 

  • Kallianpur KJ, Sakoda M, Gangcuangco LM, Ndhlovu LC, Umaki T, Chow D, Wongjittraporn S, Shikuma CM (2016b) Frailty characteristics in chronic HIV patients are markers of white matter atrophy independently of age and depressive symptoms: a pilot study. Open Med J 3:138–152

    Article  Google Scholar 

  • Mercier E, Boutin A, Lauzier F, Fergusson DA, Simard JF, Zarychanski R, Moore L, McIntyre LA, Archambault P, Lamontagne F, Legare F, Randell E, Nadeau L, Rousseau F, Turgeon AF (2013) Predictive value of S-100beta protein for prognosis in patients with moderate and severe traumatic brain injury: systematic review and meta-analysis. Bmj 346:f1757

    Article  Google Scholar 

  • Peskind ER, Griffin WS, Akama KT, Raskind MA, Van Eldik LJ (2001) Cerebrospinal fluid S100B is elevated in the earlier stages of Alzheimer’s disease. Neurochem Int 39:409–413

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors thank the many patients who made this study possible, and the staff of the Hawaii Center for AIDS, University of Hawaii.

Financial support

The study was made possible by the funding and clinical research support from NIH grants R01HL095135, U54RR026136, RMATRIX (U54MD007584), U54MD007601, and R21NS087951-01A1.

Author information

Authors and Affiliations

  1. Hawaii Center for AIDS, Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, HI, USA

    Nath Limpruttidham, Brooks I. Mitchell, Kalpana J. Kallianpur, Beau K. Nakamoto, Scott A. Souza, Bruce Shiramizu, Lishomwa C. Ndhlovu, Dominic C. Chow & Cecilia M. Shikuma

  2. University of Hawaii Internal Medicine Residency, Honolulu, HI, USA

    Nath Limpruttidham

  3. Straub Hospital, Honolulu, HI, USA

    Beau K. Nakamoto

  4. The Queen’s Medical Center, Honolulu, HI, USA

    Scott A. Souza

  5. Department of Tropical Medicine, Medical Microbiology & Pharmacology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA

    Lishomwa C. Ndhlovu

Authors
  1. Nath Limpruttidham
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Brooks I. Mitchell
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kalpana J. Kallianpur
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Beau K. Nakamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Scott A. Souza
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Bruce Shiramizu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Lishomwa C. Ndhlovu
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Dominic C. Chow
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Cecilia M. Shikuma
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nath Limpruttidham.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Limpruttidham, N., Mitchell, B.I., Kallianpur, K.J. et al. S100B and its association with HIV-associated neurocognitive disorders. J. Neurovirol. 25, 899–900 (2019). https://doi.org/10.1007/s13365-019-00773-8

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13365-019-00773-8

Search

Navigation