Central and peripheral nervous system involvement in Zika virus infection in a child


A 7-year-old boy that presented an encephalomyeloradiculitis and no classic symptoms of arboviruses. Zika virus (ZIKV) was confirmed by molecular analyses of cerebrospinal fluid and 1 year later by plaque reduction neutralization test. This case demonstrates that ZIKV can be associated with diffuse nervous system infection in children.

This is a preview of subscription content, access via your institution.

Fig. 1
Fig. 2


  1. Brazil Ministry of Health (2017) Integrated monitoring of changes in growth and development related to Zika virus infection and other infectious etiologies. Bol Epidemiol 48(6):1–18

    Google Scholar 

  2. Carteaux G, Maquart M, Bedet A, Contou D, Brugières P, Fourati S, Cleret de Langavant L, de Broucker T, Brun-Buisson C, Leparc-Goffart I, Mekontso Dessap A (2016) Zika virus associated with meningoencephalitis. N Engl J Med 374(16):1595–1596

    Article  Google Scholar 

  3. da Silva IRF, Frontera JA, Bispo de Filippis AM, Nascimento OJMD, Group R-G-ZR (2017) Neurologic complications associated with the Zika virus in Brazilian adults. JAMA Neurol 74(10):1190–1198

    Article  Google Scholar 

  4. Duca LM, Beckham JD, Tyler KL, Pastula DM (2017) Zika virus disease and associated neurologic complications. Curr Infect Dis Rep 19(1):4

    Article  Google Scholar 

  5. Krauer F, Riesen M, Reveiz L, Oladapo OT, Martínez-Vega R, Porgo TV (2017) Zika virus infection as a cause of congenital brain abnormalities and Guillain–Barré syndrome: systematic review. PLoS Med 14(1):1–27

    Article  Google Scholar 

  6. Lanciotti RS, Kosoy OL, Laven JJ, Velez JO, Lambert AJ, Johnson AJ, Stanfield SM, Duffy MR (2008) Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg Infect Dis 14(8):1232–1239

    CAS  Article  Google Scholar 

  7. Muñoz LS, Parra B, Pardo CA, NEitA S (2017) Neurological implications of Zika virus infection in adults. J Infect Dis 216(suppl_10):S897–S905

    Article  Google Scholar 

  8. Pradhan F, Burns JD, Agameya A, Patel A, Alfaqih M, Small JE, Ooi W (2017) Case report: Zika virus meningoencephalitis and myelitis and associated magnetic resonance imaging findings. Am J Trop Med Hyg 97(2):340–343

    Article  Google Scholar 

  9. Tyler KL, Roos KL (2017) The expanding Spectrum of Zika virus infections of the nervous system. JAMA Neurol 74(10):1169–1117

    Article  Google Scholar 

Download references


The authors received financial support from the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior(CAPES), Departamento de Ciência e Tecnologia (DECIT) do Ministério da Saúde and Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG). EGK is a fellow from CNPq.

Author information



Corresponding author

Correspondence to Erna Geessien Kroon.

Ethics declarations

Conflict of interest

The authors have no conflict of interest.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Marinho, P.E.S., Alvarenga, P.P.M., Lima, M.T. et al. Central and peripheral nervous system involvement in Zika virus infection in a child. J. Neurovirol. 25, 893–896 (2019). https://doi.org/10.1007/s13365-019-00770-x

Download citation


  • Zika virus
  • Central nervous system
  • Children
  • Peripheral nervous system