Abstract
We present the case of a 43-year-old-man with a past medical history of HIV with recently initiated HAART and existing PML that presented with altered mental status. The initial diagnosis was deemed to be PML-IRIS; however, neuroimaging brought into question this diagnosis. Flow cytometry performed from the cerebrospinal fluid revealed diffuse large B cell lymphoma. JC virus may act in an oncogenic role similarly to EBV and predispose to CNS lymphomas. Patients with PML caused by JC virus may develop secondary malignancies.
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Acknowledgments
We would like to acknowledge all the nurses, providers, support staff, and students for their assistance in the care of this patient. We would also like to thank Dr. Gunjan Parikh at the University of Maryland School of Medicine, for his guidance and support in creating this manuscript.
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Reddi, A., Patel, N. & Morris, N.A. Diffuse large B cell lymphoma secondary to JC virus in progressive multifocal leukoencephalopathy. J. Neurovirol. 25, 883–886 (2019). https://doi.org/10.1007/s13365-019-00760-z
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DOI: https://doi.org/10.1007/s13365-019-00760-z