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Hypertrophic chronic pachymeningitis associated with Epstein-Barr virus reactivation: a case report

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Abstract

Hypertrophic pachymeningitis is a rare inflammatory condition characterized by the thickening of the dura mater. We describe a patient who presented with intractable headache and complex cranial nerve palsy. Hypertrophy of the frontal dura was accompanied by pleocytosis and detection of Epstein-Barr virus (EBV) by PCR in cerebrospinal fluid. Clinical symptoms gradually improved after acyclovir and corticosteroid treatment, whereas dural pathology remained unchanged on neuroimaging. This case points at an expansion of the spectrum of neurological manifestations for EBV.

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Author notes

  1. Larissa Hauer and Johann Sellner contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology, Franz Tappeiner Hospital, Via Rossini 5, I-39012, Merano (BZ), Italy

    Raffaele Nardone, Francesco Brigo, Markus Covi, Luca Carnicelli, Francesca Caleri & Hannes Tischler

  2. Department of Neurology, Christian Doppler Medical Center, Salzburg, Austria

    Raffaele Nardone & Johann Sellner

  3. Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Christian Doppler Medical Center, Salzburg, Austria

    Larissa Hauer

  4. Department of Neurology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany

    Johann Sellner

Authors
  1. Raffaele Nardone
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  2. Francesco Brigo
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  3. Markus Covi
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  4. Luca Carnicelli
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  5. Francesca Caleri
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  6. Hannes Tischler
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  7. Larissa Hauer
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  8. Johann Sellner
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Corresponding author

Correspondence to Raffaele Nardone.

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Nardone, R., Brigo, F., Covi, M. et al. Hypertrophic chronic pachymeningitis associated with Epstein-Barr virus reactivation: a case report. J. Neurovirol. 25, 426–428 (2019). https://doi.org/10.1007/s13365-019-00731-4

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  • DOI: https://doi.org/10.1007/s13365-019-00731-4

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