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Vitamin D is not associated with HIV-associated neurocognitive disorder in Rakai, Uganda

Abstract

We investigated whether vitamin D is associated with HIV-associated neurocognitive disorder (HAND). HIV-infected (HIV+) antiretroviral therapy (ART)-naïve adults in rural Uganda underwent a neurocognitive battery for determination of HAND stage at baseline and after 2 years. Baseline serum 25-hydroxyvitamin D (25OH-D) and serum and cerebrospinal fluids (CSF) vitamin D-binding protein (VDBP) were obtained. Of the 399 participants, 4% (n = 16) were vitamin D deficient (25OH-D < 20 ng/mL). There was no association between 25OH-D, serum or CSF VDBP, and HAND stage at baseline or follow-up. Future studies in a population with higher levels of vitamin D deficiency may be warranted.

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Acknowledgements

The authors would like to thank the study participants and staff at the Rakai Health Sciences Program for the time and effort they dedicated to this study.

Funding

This study is supported by the National Institutes of Health (MH099733, MH075673, MH080661-08, L30NS088658, NS065729-05S2, P30AI094189-01A1) and the Johns Hopkins Center for Global Health.

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Correspondence to Deanna Saylor.

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The authors declare that they have no conflict of interest.

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Saylor, D., Nakigozi, G., Pardo, C.A. et al. Vitamin D is not associated with HIV-associated neurocognitive disorder in Rakai, Uganda. J. Neurovirol. 25, 410–414 (2019). https://doi.org/10.1007/s13365-018-00719-6

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  • DOI: https://doi.org/10.1007/s13365-018-00719-6

Keywords

  • HIV-associated neurocognitive disorder
  • Vitamin D
  • HIV
  • Africa
  • Epidemiology