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Journal of NeuroVirology

, Volume 23, Issue 4, pp 625–631 | Cite as

Immunoglobulin-responsive chikungunya encephalitis: two case reports

  • Stephanie Suzanne de O. ScottEmail author
  • Pedro Braga-Neto
  • Lícia Pacheco Pereira
  • Paulo Ribeiro Nóbrega
  • Francisco de Assis Aquino Gondim
  • Manoel Alves Sobreira-Neto
  • Claudia Carvalho Mendes Schiavon
Case Report

Abstract

Chikungunya virus is an alphavirus transmitted by the mosquito Aedes, mainly Aedes aegypti and Aedes albopictus, that can cause acute illness, mostly self-limited, characterized by fever, maculopapular rash, and disabling polyarthritis/arthralgia, with an incubation period of 1 to 12 days. Chikungunya was largely regarded as a non-fatal and self-limited disease, but recently, serious cases have been reported including some with severe involvement of the nervous system, such as meningoencephalitis, myelitis, polyradiculitis, and polyradiculoneuropathy. In this report, we describe the clinical and laboratory findings of two patients with encephalitis associated with chikungunya in a northeastern city in Brazil, who exhibited a good outcome, with improvement after treatment with i.v. immunoglobulin (IVIg).

Keywords

Encephalitis Chikungunya Immunoglobulin Treatment 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Journal of NeuroVirology, Inc. 2017

Authors and Affiliations

  • Stephanie Suzanne de O. Scott
    • 1
    Email author
  • Pedro Braga-Neto
    • 2
    • 3
  • Lícia Pacheco Pereira
    • 1
  • Paulo Ribeiro Nóbrega
    • 1
  • Francisco de Assis Aquino Gondim
    • 2
  • Manoel Alves Sobreira-Neto
    • 2
    • 4
  • Claudia Carvalho Mendes Schiavon
    • 1
  1. 1.Hospital Universitário Walter CantídioUniversidade Federal do CearáFortalezaBrazil
  2. 2.Department of Clinical MedicineUniversidade Federal do CearáFortalezaBrazil
  3. 3.Center of Health SciencesUniversidade Estadual do CearáFortalezaBrazil
  4. 4.Universidade de FortalezaFortalezaBrazil

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