2nd International Conference on Progressive Multifocal Leukoencephalopathy (PML) 2015: JCV virology, progressive multifocal leukoencephalopathy pathogenesis, diagnosis and risk stratification, and new approaches to prevention and treatment
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Progressive multifocal leukoencephalopathy (PML) is a rare but serious demyelinating disease of the brain that can result in severe disability or death. PML is caused by infection of oligodendrocytes by the neuropathogenic form of JC polyomavirus (JCV). There is a high prevalence of chronic but asymptomatic JCV infection in the general population. However, the incidence of PML is relatively low due to the requirement for transformation of an otherwise non-pathogenic virus to a neuropathogenic form, which is a slowly evolving process typically occuring in individuals with compromised immune system.
Notable progress has been made in defining risk factors for PML, but advances in diagnosis, accurate susceptibility prediction, prevention, and treatment lag. The “2nd International Conference on Progressive Multifocal Leukoencephalopathy,” held in Mölndal, Sweden, on August 25–26, 2015, brought together scientists, clinicians, and regulatory experts from academia, industry,...
KeywordsProgressive Multifocal Leukoencephalopathy Natalizumab Cidofovir Progressive Multifocal Leukoencephalopathy Maraviroc
The authors would like to acknowledge the Progressive Multifocal Leukoencephalopathy Consortium’s Board of Directors for its support of the research conference; the conference speakers and attendees who contributed to the discussions presented herein; Drs. Len Calabrese and Marianne Gerber, who also contributed to organization of the conference; and the PML Consortium Secretariat and AstraZeneca for their organizational support.
Compliance with ethical standards
Conflict of interest
AstraZeneca/MedImmune, Pfizer, and Roche are PML Consortium member companies. D. Pavlovic and M. Gerber are members of the PMLC Clinical Working Group. A. Patera, S. Butler, and R. Elston are members of the PMLC Research Working Group. Dejan Pavlovic and Andriani Patera are employees of MedImmune, the global biologics research and development arm of AstraZeneca, and own stock in AstraZeneca. Robert Elston and Marianne Gerber are employees of and own stock in F. Hoffmann-La Roche AG. Scott Butler and Anne Ryan are employees of and own stock in Pfizer Inc.
David B. Clifford, Robert L. Garcea, Eugene O. Major, Kenneth L. Tyler, and Thomas Weber are members of the PML Consortium Scientific Advisory Board. Kenneth Tyler has served as a scientific consultant or scientific advisory board member for Hoffman La Roche, Biogen, Genentech, Johnson & Johnson, and Pfizer.
Paola Cinque is a PML Consortium grantee and has received funding from the Consortium to support her research.
Ilse Peterson is an employee of Drinker Biddle & Reath, LLP, which serves as the PML Consortium Secretariat, and has no conflicts of interest to report.
Related online content
Since work described herein is primarily unpublished, titles of presentations are referenced below to allow readers to view the recorded presentations posted on www.pmlconsortium.org.
- Atwood W. Human polyoma virus receptor distribution. Session 1Google Scholar
- Berger J. PML associated with neurologic therapies. Session 3Google Scholar
- Buck C. Developing vaccines against JC polyomavirus. Session 4Google Scholar
- Clifford D. PML treatment/IRIS. Session 4Google Scholar
- DiMaio D. Cellular factors required for infection by small DNA viruses. Session 1Google Scholar
- Enquist L. Axons, the front line sensors of alpha herpes virus PNS invasion. Session 1Google Scholar
- Hirsch H. Testing JC and BK PyV antibody responses: why and how. Session 2Google Scholar
- Imperiale M. Trafficking of BKPyV to the nucleus. Session 1Google Scholar
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