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Human T-lymphotropic virus type 2 subtype b in a patient with chronic neurological disorder

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References

  • Araujo A, Hall WW (2004) Human T-lymphotropic virus type II and neurological disease. Ann Neurol 56:10–19. doi:10.1002/ana.20126

    Article  PubMed  Google Scholar 

  • Biswas HH, Engstrom JW, Kaidarova Z et al (2009) Neurologic abnormalities in HTLV-I- and HTLV-II-infected individuals without overt myelopathy. Neurology 73:781–789. doi:10.1212/WNL.0b013e3181b6bba9

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Harrington WJ, Sheremata W, Hjelle B et al (1993) Spastic ataxia associated with human T-cell lymphotropic virus type II infection. Ann Neurol 33:411–414. doi:10.1002/ana.410330416

    Article  PubMed  Google Scholar 

  • Higuchi M, Fujii M (2009) Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis. Retrovirology 6:117. doi:10.1186/1742-4690-6-117

    Article  PubMed Central  PubMed  Google Scholar 

  • Jacobson S, Lehky T, Nishimura M et al (1993) Isolation of HTLV-II from a patient with chronic, progressive neurological disease clinically indistinguishable from HTLV-I-associated myelopathy/tropical spastic paraparesis. Ann Neurol 33:392–396. doi:10.1002/ana.410330411

    Article  CAS  PubMed  Google Scholar 

  • Lehky TJ, Flerlage N, Katz D et al (1996) Human T-cell lymphotropic virus type II-associated myelopathy: clinical and immunologic profiles. Ann Neurol 40:714–723. doi:10.1002/ana.410400507

    Article  CAS  PubMed  Google Scholar 

  • Melamed A, Laydon DJ, Gillet NA et al (2013) Genome-wide determinants of proviral targeting, clonal abundance and expression in natural HTLV-1 infection. PLoS Pathog 9:e1003271. doi:10.1371/journal.ppat.1003271

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Morimoto HK, Morimoto AA, Reiche EMV et al (2007) Difficulties in the diagnosis of HTLV-2 infection in HIV/AIDS patients from Brazil: Comparative performances of serologic and molecular assays, and detection of HTLV-2b subtype. Rev Inst Med Trop Sao Paulo 49:225–230

    Article  PubMed  Google Scholar 

  • Murphy EL, Lee T-H, Chafets D et al (2004) Higher human T lymphotropic virus (HTLV) provirus load is associated with HTLV-I versus HTLV-II, with HTLV-II subtype A versus B, and with male sex and a history of blood transfusion. J Infect Dis 190:504–510. doi:10.1086/422398

    Article  PubMed  Google Scholar 

  • Osame M (1990) Review of WHO Kagoshima meeting and diagnostic guidelines for HAM/TSP. Hum Retrovirol HTLV 191–197

  • Puccioni-Sohler M, Rios M, Carvalho SM et al (2001) Diagnosis of HAM/TSP based on CSF proviral HTLV-I DNA and HTLV-I antibody index. Neurology 57:725–727

    Article  CAS  PubMed  Google Scholar 

  • Rosadas C, Cabral-Castro MJ, Vicente ACP et al (2013) Validation of a quantitative real-time PCR assay for HTLV-1 proviral load in peripheral blood mononuclear cells. J Virol Methods 193:536–541. doi:10.1016/j.jviromet.2013.07.040

    Article  CAS  PubMed  Google Scholar 

  • Silva EA, Otsuki K, Leite ACB et al (2002) HTLV-II infection associated with a chronic neurodegenerative disease: Clinical and molecular analysis. J Med Virol 257:253–257. doi:10.1002/jmv.2138

    Article  Google Scholar 

  • Silva MTT, Harab RC, Leite AC et al (2007) Human T lymphotropic virus type 1 (HTLV-1) proviral load in asymptomatic carriers, HTLV-1-associated myelopathy/tropical spastic paraparesis, and other neurological abnormalities associated with HTLV-1 infection. Clin Infect Dis 44:689–692. doi:10.1086/510679

    Article  PubMed  Google Scholar 

  • Sofian M, Aghakhani A, Farazi AA et al (2012) Serum profile of T helper 1 and T helper 2 cytokines in hepatitis C virus infected patients. Hepat Mon 12:e6156. doi:10.5812/hepatmon.6156

    Article  PubMed Central  PubMed  Google Scholar 

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Acknowledgments

To PDTIS/FIOCRUZ sequencing platform.

This work was supported by Fundação de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ) and by Post-Graduation on Infectious and Parasitic Diseases (UFRJ), a PhD fellowship to C.R. from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), and a PhD fellowship to M.J.C.C. and L.Z. from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).

Conflict of interests

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil

    Carolina Rosadas, Mauro J. Cabral-Castro, José M. Peralta & Marzia Puccioni-Sohler

  2. Laboratory of Molecular Genetics of Microorganisms, Fundação Oswaldo Cruz (IOC-FIOCRUZ), Rio de Janeiro, Brazil

    Ana C. P. Vicente & Louise Zanella

  3. Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Rio de Janeiro, Brazil

    Marzia Puccioni-Sohler

  4. Faculdade de Medicina, Universidade Federal do Rio de Janeiro (UFRJ), Laboratório de Líquido Cefalorraquiano, SPC, Hospital Universitário Clementino Fraga Filho, (HUCFF/UFRJ), Rua Professor Rodolpho Paulo Rocco 255, 3 andar, 21941-913, Rio de Janeiro, RJ, Brazil

    Carolina Rosadas, Mauro J. Cabral-Castro & Marzia Puccioni-Sohler

Authors
  1. Carolina Rosadas
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  2. Ana C. P. Vicente
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  3. Louise Zanella
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  4. Mauro J. Cabral-Castro
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  5. José M. Peralta
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  6. Marzia Puccioni-Sohler
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Corresponding authors

Correspondence to Carolina Rosadas or Marzia Puccioni-Sohler.

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Rosadas, C., Vicente, A.C.P., Zanella, L. et al. Human T-lymphotropic virus type 2 subtype b in a patient with chronic neurological disorder. J. Neurovirol. 20, 636–639 (2014). https://doi.org/10.1007/s13365-014-0280-4

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  • DOI: https://doi.org/10.1007/s13365-014-0280-4

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