Abstract
Like varicella zoster virus in humans, simian varicella virus (SVV) becomes latent in ganglionic neurons along the entire neuraxis and reactivates in immunosuppressed monkeys. Five rhesus macaques were inoculated with SVV; 142 days later (latency), four monkeys were immunosuppressed, and T cells were analyzed for naïve, memory, and effector phenotypes and expression of programmed death receptor-1 (PD-1; T cell exhaustion). All T cell subsets decreased during immunosuppression and except for CD8 effectors, peaked 2 weeks before zoster. Compared to before immunosuppression, PD-1 expression increased at reactivation. Increased T cells before zoster is likely due to virus reactivation.
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Acknowledgments
This work was supported by Public Health Service grants AG032958 (D.G.). Dr. James was supported by taining grant NS007321 to Dr. Gilden from the National Institutes of Health and to Dr. Traina-Dorge in part with federal funds from National Center for Research Resources and the Office of Research Infrastructure Programs (ORIP) through grant P51 RR001464 to the Tulane National Primate Research Center. We thank Marina Hoffman for editorial review and Lori DePriest for manuscript preparation.
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James, S.F., Traina-Dorge, V., Deharo, E. et al. T cells increase before zoster and PD-1 expression increases at the time of zoster in immunosuppressed nonhuman primates latently infected with simian varicella virus. J. Neurovirol. 20, 309–313 (2014). https://doi.org/10.1007/s13365-014-0237-7
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DOI: https://doi.org/10.1007/s13365-014-0237-7