Skip to main content

Advertisement

SpringerLink
Log in

Tumefactive demyelination in a patient with human immunodeficiency virus

  • Case Report
  • Published:
Journal of NeuroVirology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  • Ball SC (2004) Rapid neurologic deterioration in a patient with HIV infection. AIDS Read 14:63–66, 69

    PubMed  Google Scholar 

  • Berger JR, Sheremata WA, Resnick L, Atherton S, Fletcher MA, Norenberg M (1989) Multiple sclerosis-like illness occurring with human immunodeficiency virus infection. Neurology 39:324–329

    Article  PubMed  CAS  Google Scholar 

  • Gray F, Lescs MC (1993) HIV-related demyelinating disease. Eur J Med 2:89–96

    PubMed  CAS  Google Scholar 

  • Gray F, Lescure FX, Adle-Biassette H, Polivka FM, Gallien S, Pialoux G, Moulignier A (2013) Encephalitis with infiltration by CD8+ Lymphocytes in HIV Patients receiving Combination Antiretroviral Treatment. Brain Pathol

  • Kepes JJ (1993) Large focal tumor-like demyelinating lesions of the brain: intermediate entity between multiple sclerosis and acute disseminated encephalomyelitis? A study of 31 patients. Ann Neurol 33:18–27

    Article  PubMed  CAS  Google Scholar 

  • Langford TD, Letendre SL, Marcotte TD, Ellis RJ, McCutchan JA, Grant I, Mallory ME, Hansen LA, Archibald S, Jernigan T, Masliah E (2002) Severe, demyelinating leukoencephalopathy in AIDS patients on antiretroviral therapy. AIDS 16:1019–1029

    Article  PubMed  Google Scholar 

  • Lindzen E, Jewells V, Bouldin T, Speer D, Royal W 3rd, Markovic-Plese S (2008) Progressive tumefactive inflammatory central nervous system demyelinating disease in an acquired immunodeficiency syndrome patient treated with highly active antiretroviral therapy. J Neurovirol 14:569–573

    Article  PubMed  Google Scholar 

  • Nagappa M, Taly AB, Sinha S, Bharath RD, Mahadevan A, Bindu PS, Saini JS, Prasad C, Shankar SK (2012) Tumefactive demyelination: clinical, imaging and follow-up observations in thirty-nine patients. Acta Neurol Scand. doi:10.1111/ane.12071

    PubMed  Google Scholar 

  • Narciso P, Galgani S, Del Grosso B, De Marco M, De Santis A, Balestra P, Ciapparoni V, Tozzi V (2001) Acute disseminated encephalomyelitis as manifestation of primary HIV infection. Neurology 57:1493–1496

    Article  PubMed  CAS  Google Scholar 

  • Netherton C, Moffat K, Brooks E, Wileman T (2007) A guide to viral inclusions, membrane rearrangements, factories, and viroplasm produced during virus replication. Adv Virus Res 70:101–182

    Article  PubMed  CAS  Google Scholar 

  • Saravanan M, Turnbull IW (2009) Brain: non-infective and non-neoplastic manifestations of HIV. Br J Radiol 82:956–965

    Article  PubMed  CAS  Google Scholar 

  • Uriel A, Stow R, Johnson L, Varma A, du Plessis D, Gray F, Herwadkar A, Holland J, Lewthwaite P, Wilkins E (2010) Tumefactive demyelination-an unusual neurological presentation of HIV. Clin Infect Dis 51:1217–1220

    Article  PubMed  Google Scholar 

  • Virtanen JO, Jacobson S (2012) Viruses and multiple sclerosis. CNS Neurol Disord Drug Targets 11:528–544

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

Funding sources include National Institute of Allergy and Infectious Diseases (NIAID) (UM1AI069495) (DBC), National Institute of Mental Health (NIMH) (K23MH081786) (BMA), National Institute of Neurological Disorders and Stroke (NINDS) (U10NS077384) (DBC) and (F30NS063547) (IHS), National Institute of Nursing Research (NINR) (R01NR012907 and R01NR012657) (BMA), NM22005 (DBC), and Alzheimer’s Association (with partial support from Lilly and Roche) (BMA and DBC). DBC has consulted for Pfizer, Genzyme, Millennium, Brinker, Biddle, Reath, Amgen, Quintiles, Biogen Idec, Arnold Todara and Welch.

Author information

Authors and Affiliations

  1. Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA

    Isaac H. Solomon, David B. Clifford & Beau M. Ances

  2. Division of Neuropathology, Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO, USA

    Richard J. Perrin

  3. Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St. Louis, MO, 63110, USA

    Beau M. Ances

Authors
  1. Isaac H. Solomon
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Richard J. Perrin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. David B. Clifford
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Beau M. Ances
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Beau M. Ances.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Solomon, I.H., Perrin, R.J., Clifford, D.B. et al. Tumefactive demyelination in a patient with human immunodeficiency virus. J. Neurovirol. 19, 265–269 (2013). https://doi.org/10.1007/s13365-013-0165-y

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13365-013-0165-y

Keywords

Search

Navigation