Abstract
Although Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) remains the mass spectrometry platform that provides the highest levels of performance for mass accuracy and resolving power, there is room for improvement in analyzer cell design as the ideal quadrupolar trapping potential has yet to be generated for a broadband MS experiment. To this end, analyzer cell designs have improved since the field’s inception, yet few research groups participate in this area because of the high cost of instrumentation efforts. As a step towards reducing this barrier to participation and allowing for more designs to be physically tested, we introduce a method of FT-ICR analyzer cell prototyping utilizing printed circuit boards at modest vacuum conditions. This method allows for inexpensive devices to be readily fabricated and tested over short intervals and should open the field to laboratories lacking or unable to access high performance machine shop facilities because of the required financial investment.
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Acknowledgments
F.E.L. III gratefully acknowledges the contributions of Dick Smith to the technological advancement of FT-ICR MS and mass spectrometry in general. This work was supported by the U.S. Department of Energy (DOE) Office of Biological and Environmental Research. Experiments were performed in the Environmental Molecular Science Laboratory (EMSL), a DOE national scientific user facility located on the campus of Pacific Northwest National Laboratory (PNNL) in Richland, WA, USA. PNNL is a multi-program national laboratory operated by Battelle for the DOE under Contract DE-AC05-76RLO 1830.
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Leach, F.E., Norheim, R., Anderson, G. et al. Application of Printed Circuit Board Technology to FT-ICR MS Analyzer Cell Construction and Prototyping. J. Am. Soc. Mass Spectrom. 25, 2069–2072 (2014). https://doi.org/10.1007/s13361-014-0952-6
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DOI: https://doi.org/10.1007/s13361-014-0952-6