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Multiple Mass Analysis Using an Ion Trap Array (ITA) Mass Analyzer

  • Research Article
  • Published:
Journal of The American Society for Mass Spectrometry

Abstract

A novel ion trap array (ITA) mass analyzer with six ion trapping and analyzing channels was investigated. It is capable of analyzing multiple samples simultaneously. The ITA was built with several planar electrodes made of stainless steel and 12 identical parallel zirconia ceramic substrates plated with conductive metal layers. Each two of the opposing ceramic electrode plates formed a boundary of an ion trap channel and six identical ion trapping and analyzing channels were placed in parallel without physical electrode between any two adjacent channels. The electric field distribution inside each channel was studied with simulation. The new design took the advantage of high precision machining attributable to the rigidity of ceramic, and the convenience of surface patterning technique. The ITA system was tested by using a two-channel electrospray ionization source, a multichannel simultaneous quadruple ion guide, and two detectors. The simultaneous analysis of two different samples with two adjacent ITA channels was achieved and independent mass spectra were obtained. For each channel, the mass resolution was tested. Additional ion trap functions such as mass-selected ion isolation and collision-induced dissociation (CID) were also tested. The results show that one ITA is well suited for multiple simultaneous mass analyses.

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Acknowledgments

The authors gratefully acknowledge financial support from the National Ministry of Science and Technology of China, for the National Science and Technology Support Program of China (2009BAK60B03).

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Authors and Affiliations

  1. Department of Chemistry and Laser Chemistry Institute, Fudan University, Shanghai, 200433, China

    Yu Xiao, Yanqiu Chu, Xing Ling, Zhengzhi Ding, Chongsheng Xu & Chuan-Fan Ding

  2. Shimadzu Research Laboratory (Europe) Ltd., Manchester, M17 1GP, UK

    Li Ding

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  1. Yu Xiao
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  2. Yanqiu Chu
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  3. Xing Ling
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  4. Zhengzhi Ding
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  5. Chongsheng Xu
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  7. Chuan-Fan Ding
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Correspondence to Chuan-Fan Ding.

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Xiao, Y., Chu, Y., Ling, X. et al. Multiple Mass Analysis Using an Ion Trap Array (ITA) Mass Analyzer. J. Am. Soc. Mass Spectrom. 24, 1420–1427 (2013). https://doi.org/10.1007/s13361-013-0679-9

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