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Traveling Wave Ion Mobility Mass Spectrometry Study of Low Generation Polyamidoamine Dendrimers

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Journal of The American Society for Mass Spectrometry

Abstract

We reported the use of ion mobility (IM) combined with mass spectrometry (MS) as an analytical tool to investigate low generation polyamidoanine (PAMAM) dendrimers. This analytical approach has been employed to separate ions of defective structures with different charge state but exactly the same m/z value. Tandem mass spectrometry (MS/MS) after IM separation allowed a comprehensive structural characterization of defective dendrimers. In addition, IM was used to evaluate the collision cross-sections of ions of perfect dendrimers. They showed a good correlation with calculated collision cross-sections obtained by the trajectory method (TM) and were also consistent with dimensions reported by other established analytical methods.

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Acknowledgments

The authors thank the Région Haute-Normandie and the European Regional Development Fund (ERDF) for financial support.

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Authors and Affiliations

  1. Université de Rouen, IRCOF, Mont-Saint-Aignan, France

    Florian Maire, Gael Coadou & Catherine M. Lange

  2. INSA de Rouen, Saint-Etienne-du-Rouvray, France

    Florian Maire, Gael Coadou & Catherine M. Lange

  3. CNRS UMR 6014, COBRA, Mont-Saint-Aignan, France

    Florian Maire, Gael Coadou & Catherine M. Lange

  4. Waters Corporation, Manchester, UK

    Laetitia Cravello

Authors
  1. Florian Maire
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  2. Gael Coadou
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Correspondence to Catherine M. Lange.

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Maire, F., Coadou, G., Cravello, L. et al. Traveling Wave Ion Mobility Mass Spectrometry Study of Low Generation Polyamidoamine Dendrimers. J. Am. Soc. Mass Spectrom. 24, 238–248 (2013). https://doi.org/10.1007/s13361-012-0527-3

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