Journal of Applied Genetics

, Volume 59, Issue 2, pp 161–168 | Cite as

Tip60: updates

  • Ahmed H. Ghobashi
  • Maher A. Kamel
Human Genetics • Review


The maintenance of genome integrity is essential for organism survival. Therefore, eukaryotic cells possess many DNA repair mechanisms in response to DNA damage. Acetyltransferase, Tip60, plays a central role in ATM and p53 activation which are involved in DNA repair. Recent works uncovered the roles of Tip60 in ATM and p53 activation and how Tip60 is recruited to double-strand break sites. Moreover, recent works have demonstrated the role of Tip60 in cancer progression. Here, we review the current understanding of how Tip60 activates both ATM and p53 in response to DNA damage and his new roles in tumorigenesis.


Tip60 protein p53 ATM kinase Double-strand break DNA repair Histone methylation Cancer 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Institute of Plant Genetics, Polish Academy of Sciences, Poznan 2018

Authors and Affiliations

  1. 1.Human Genetics Department, Medical Research InstituteAlexandria UniversityAlexandriaEgypt
  2. 2.Biochemistry Department, Medical Research InstituteAlexandria UniversityAlexandriaEgypt

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