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Relationship of long-term prognosis to MMP and TIMP polymorphisms in patients after ST elevation myocardial infarction

  • Human Genetics • Original Paper
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Abstract

The influence of polymorphisms in the large group of MMP and TIMP genes on clinical outcomes in patients after ST elevation myocardial infarction (STEMI) treated with primary PCI was analysed. In total, 550 consecutive Caucasian patients with STEMI were included in the present study, with a median of 32 months. We analysed 19 polymorphisms in the genes coding MMP and TIMP genes. The MMP-1 -519A/G and -422A/T polymorphisms are associated with combined endpoint after myocardial infarction. The hazard ratio for AT variant of MMP-1 -422A/T was 1.75 (p < 0.001); the variants with at least one A allele of MMP-1 -519A/G have less risk of combined endpoint. The TT variants of -1562C/T MMP-9 and at least one T allele of +92C/T MMP-13 were considered in a trend to affect disease progression and long-term survival after myocardial infarction. According to reclassification analysis NRI and IDI, long-term risk stratification using MMP-1 -422A/T and -519A/G polymorphisms gives additional information to the commonly used GRACE risk score. Patient stratification after myocardial infraction (MI) according to risk genotypes of MMP-1 polymorphisms could have important clinical implications for identification of patients at risk and therapeutic strategies.

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Authors and Affiliations

  1. Faculty of Medicine, Masaryk University, Brno, Czech Republic

    Monika Pavkova Goldbergova, Jolana Lipkova, Martin Poloczek, Jindrich Spinar, Lenka Kubkova, Krystyna Kluz, Petr Kala, Jan Manousek, Anna Vasku & Jiri Parenica

  2. Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic

    Jiri Jarkovsky & Simona Littnerova

  3. Cardiology Department, Faculty Hospital Brno, Brno, Czech Republic

    Martin Poloczek, Jindrich Spinar, Lenka Kubkova, Petr Kala, Jan Manousek & Jiri Parenica

  4. International Clinical Research Center – Department of Cardiovascular Disease, University Hospital St. Annes’s, Brno, Czech Republic

    Jindrich Spinar, Lenka Kubkova & Jiri Parenica

  5. Hospital Podlesi a.s., Trinec, Czech Republic

    Krystyna Kluz

  6. Cardiology Department, University Hospital Brno, Jihlavska 20, Brno, 625 00, Czech Republic

    Jiri Parenica

Authors
  1. Monika Pavkova Goldbergova
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  2. Jiri Jarkovsky
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  3. Jolana Lipkova
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  4. Simona Littnerova
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  5. Martin Poloczek
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  6. Jindrich Spinar
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  7. Lenka Kubkova
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  8. Krystyna Kluz
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  9. Petr Kala
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  10. Jan Manousek
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  11. Anna Vasku
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  12. Jiri Parenica
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Corresponding author

Correspondence to Jiri Parenica.

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Funding

This study was funded by the Project of Conceptual Development of Research Organization (Department of Health, University Hospital Brno) (No. 65269705) and by the European Regional Development Fund — Project FNUSA-ICRC (No. CZ.1.05/1.1.00/02.0123).

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the the local Ethics Committee of the University Hospital Brno and by the Ethics Committee of the Masaryk University (Brno, Czech Republic) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Communicated by: Michal Witt

All authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.

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Pavkova Goldbergova, M., Jarkovsky, J., Lipkova, J. et al. Relationship of long-term prognosis to MMP and TIMP polymorphisms in patients after ST elevation myocardial infarction. J Appl Genetics 58, 331–341 (2017). https://doi.org/10.1007/s13353-016-0388-8

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  • DOI: https://doi.org/10.1007/s13353-016-0388-8

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