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Bibliometric and visualized analysis of cancer nanomedicine from 2013 to 2023

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Abstract

Cancer nanomedicine has been an emerging field for drug development against malignant tumors during the past three decades. A bibliometric analysis was performed to characterize the current international trends and present visual representations of the evolution and emerging trends in the research and development of nanocarriers for cancer treatment. This study employed bibliometric analysis and visualization techniques to analyze the literature on antitumor nanocarriers published between 2013 and 2023. A total of 98,980 articles on antitumor nanocarriers were retrieved from the Web of Science Core Collection (WoSCC) database and analyzed using the Citespace software for specific characteristics such as publication year, countries/regions, organizations, keywords, and references. Network visualization was constructed by VOSviewer and Citespace. From 2013 to 2023, the annual global publications increased 7.39 times, from 1851 to 13,683. People’s Republic of China (2588 publications) was the most productive country. Chinese Academy of Sciences (298 publications) was the most productive organization. The top 5 high-frequency keywords were “nanoparticles,” “drug delivery,” “nanomedicine,” “cancer,” and “nanocarriers.” The keywords with the strongest citation bursts recently were “cancer immunotherapy,” “microenvironment,” “antitumor immunity,” etc., which indicated the emerging frontiers of antitumor nanomedicine. The co-occurrence cluster analysis of the keywords formed 6 clusters, and most of the top 10 publications by citation counts focused on cluster #1 (nanocarriers) and cluster #2 (cancer immunotherapy). We further provided insightful discussions into the identified subtopics to help researchers gain more details of current trends and hotspots in this field. The present study processes a macro-level literature analysis of antitumor nanocarriers and provides new perspectives and research directions for future development in cancer nanomedicine.

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Acknowledgements

The authors are grateful for the support provided by the First Affiliated Hospital of Soochow University, Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences of Soochow University.

Funding

This work was supported by National Natural Science Foundation of China (81703512 and 31500811), Basic Research Project of Suzhou (SKY2023136).

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Author notes

  1. Jing Tao and Xiaoming Yuan contributed equally to this work.

Authors and Affiliations

  1. Department of Pharmacy, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China

    Jing Tao & Jianguo Zhu

  2. Soochow University Library, Soochow University, Suzhou, 215006, China

    Xiaoming Yuan

  3. Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China

    Min Zheng, Yingqian Jiang, Yitian Chen, Fangrui Zhang, Nan Zhou & Yibin Deng

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  1. Jing Tao
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  2. Xiaoming Yuan
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  3. Min Zheng
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  5. Yitian Chen
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Contributions

JT led the writing, editing, and overseeing of the manuscript. XY and MZ collected the data and edited the graphs. YJ, YC, FZ, and NZ worked on writing various sections for the manuscript. JZ and YD oversaw this work and revised the final manuscript.

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Correspondence to Jing Tao, Jianguo Zhu or Yibin Deng.

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Tao, J., Yuan, X., Zheng, M. et al. Bibliometric and visualized analysis of cancer nanomedicine from 2013 to 2023. Drug Deliv. and Transl. Res. 14, 1708–1724 (2024). https://doi.org/10.1007/s13346-023-01485-7

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