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CODAS® (chronotherapeutic oral drug absorption system)
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Non-enteric release-controlling polymers applied to drug-loaded beads where the release-controlling polymer is a combination of water-soluble and waster-insoluble polymers resulting in pH-independent drug release
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Verapamil (Elan Drug Technologies, Dublin, Republic of Ireland)
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OROS®
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A ‘push–pull’ multi-layer tablet system for poorly water-soluble drugs. The ‘pull’ drug layer contains the poorly soluble drug, suspending and osmotic agents with the ‘push’ layer containing water-soluble swellable polymers
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Nifedipine (ALZA Corp, CA, USA)
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Geoclock®
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Press-coated tablets with slow release outer coat and an immediate-release inner core to allow pH-independent timed release of drug
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Prednisolone (SkyPharma, London, UK)
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Diffucaps®
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A multi-particulate bead system comprising multiple layers of drug, excipients and release-controlling polymers
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Cyclobenzaprine (Eurand, OH, USA)
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Pulsys®
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Multi-component tablet consisting of one immediate-release and two delayed-release components
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Amoxicillin (Middlebrook Pharmaceuticals, MD, USA)
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Pulsincap™
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Non-disintegrating half capsule body sealed at the open end with a hydrogel plug that is covered with a water-soluble cap
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Diclofenac sodium (RP Sherer Corporation, MI, USA)
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