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Cell-based carrier for targeted hitchhiking delivery

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Abstract

Drug delivery systems aim at improving drug transport efficiency and therapeutic efficacy by rational design, and current research on conventional delivery systems brings new developments for disease treatment. Recently, studies on cell-based drug delivery systems are rapidly emerging, which shows great advantages in comparison to conventional drug delivery system. The system uses cells as carriers to delivery conventional drugs or nanomedicines and shows good biocompatibility and enhanced targeting efficiency, beneficial from self component and its physiological function. The construction methodology of cell-based carrier determines the effect on the physiological functions of transporting cell and affects its clinical application. There are different strategies to prepare cell-based carrier, such as direct internalization or surface conjugation of drugs or drug loaded materials. Thus, it is necessary to fully understand the advantages and disadvantages of different strategies for constructing cell-based carrier and then to seek the appropriate construction methodology for achieving better therapeutic results based on disease characterization. We here summarize the application of different types of cell-based carriers reported in recent years and further discuss their applications in disease therapy and the dilemmas faced in clinical translation. We hope that this summary can accelerate the process of clinical translation by promoting the technology development of cell-based carrier.

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Acknowledgements

We tender our apologies to those authors whose deserving research was not cited in this manuscript. Tonggong Liu and Cheng Gao contributed equally to this work.

Funding

This research was supported by the National Key Research and Development Program of China [No.2018YFC0809200], Guangdong Science and Technology Foundation [No. 2020B1111160001, B2019228], Shenzhen Science and Technology Foundation [GJHZ20200731095604013, RCBS20200714114856016, JCYJ20210324103204011, No. SGLH20180625171602058, No. 201906133000069] and the Open Project of Key Laboratory of Tropical Disease Control of the Ministry of Education (Sun Yat-Sen University) [No. 2019kfkt06], National Natural Science Foundation of China [No. 82073582 and 32001016], Discipline construction project of Guangdong Medical University [4SG21004G], Guangdong Provincial University Key Platform Featured Innovation Project [No. 2020KTSCX048], GuangDong Basic and Applied Basic Research Foundation [2020A1515110871], China Postdoctoral Science Foundation [2021T140479, 2020M682903].

Author information

Author notes

  1. Tonggong Liu and Cheng Gao contributed equally to this work.

Authors and Affiliations

  1. Department of Preventive Medicine, School of Public Health, Dongguan Key Laboratory of Environmental Medicine, Guangdong Medical University, Dongguan, 523808, China

    Tonggong Liu & Huanwen Tang

  2. Department of Laboratory Medicine, Shenzhen Institute of Translational Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, Shenzhen, 518035, China

    Tonggong Liu, Cheng Gao & Dayong Gu

  3. Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

    Cheng Gao

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  1. Tonggong Liu
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  2. Cheng Gao
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  3. Dayong Gu
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  4. Huanwen Tang
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Correspondence to Dayong Gu or Huanwen Tang.

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Liu, T., Gao, C., Gu, D. et al. Cell-based carrier for targeted hitchhiking delivery. Drug Deliv. and Transl. Res. 12, 2634–2648 (2022). https://doi.org/10.1007/s13346-022-01149-y

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