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Recent advances on microneedle arrays-mediated technology in cancer diagnosis and therapy

  • Review Article
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Abstract

Regarding the increasing prevalence of cancer throughout the globe, the development of novel alternatives for conventional therapies is inevitable to circumvent limitations such as low efficacy, complications, and high cost. Recently, microneedle arrays (MNs) have been introduced as a novel, minimally invasive, and low-cost approach. MNs can delivery both small molecule and macromolecular drugs or even nanoparticles (NPs) to the tumor tissue in a safe and controlled manner. Relying on the recent promising outcomes of MNs in transdermal delivery of anticancer agents, this review is aimed to summarize constituent materials, fabrication methods, advantages, and limitations of different types of MNs used in cancer therapy applications. This review paper also presents the potential use of MNs in transdermal delivery of NPs for effective chemotherapy, gene therapy, immunotherapy, photodynamic, and photothermal therapy. Additionally, MNs are currently explored as routine point-of-care health monitoring devices for transdermal detection of cancer biomarkers or physiologically relevant analytes which will be addressed in this paper. Despite the promising potential of MNs for cancer therapy and diagnosis, several limitations have impeded their therapeutic efficacy and real-time applicability that are addressed in this paper.

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Abbreviations

1-MT:

1-Methyl-DL-tryptophan

mHA:

1-MT-conjugated HA

5-ALA:

5-Aminolevulinic acid

5-FU:

5-Fluorouracil

Ac-DEX:

Acetal-modified dextran

aCTLA4:

Anti-CTLA4

APC:

Antigen-presenting cells

aPD1:

Anti-PD-1

AuNCs:

Au nanocages

CNTs:

Carbon nanotubes

CMC:

Carboxymethyl cellulose

CEA:

Carcinoembryonic antigen

CSMNs:

Core-shell structure microneedles

CLIP:

Continuous liquid interface production

PMVE/MA:

Copolymer of methyl vinyl ether and maleic anhydride

CMOS:

Complementary metal-oxide-semiconductor

CTL:

Cytolytic T lymphocytes

CTLA4:

Cytotoxic T lymphocyte-associated molecule-4

DAMPs:

Damage-associated molecular patterns

DCs:

Dendritic cells

DTX:

Docetaxel

DOX:

Doxorubicin

Teffs:

Effective T cells

GOx:

Glucose oxidase

GFNs:

Graphene family nanomaterials

HPV:

Human papillomavirus

HA:

Hyaluronic acid

HAase:

Hyaluronidase

HEM:

Hybrid electro-MNs

ICG:

Indocyanine green

iNOS:

Inducible NO synthase

IP:

Intraperitoneal

I.V.:

Intravenous

LCs:

Langerhans cells

LaB6:

Lanthanum hexaboride

LDH:

Layered double hydroxides

LCC-NPs:

Lipid-coated cisplatin nanoparticles

LIGA:

Lithography, electroplating, and molding

CPP-PEI1800-Man:

Mannosylated TAT peptide-grafted low molecular weight PEI

MBGs:

Mesoporous bioactive glasses

MSNs:

Mesoporous silica nanoparticles

MPEG-PDLLA-DTX:

Methoxy-poly (ethylene glycol) poly (D, L-lactide) micelles

ZnONW-MGP:

Microbubble generator probe

MIM:

Microinjection molding

MNs:

Microneedle arrays

MDR:

Multi-drug resistance

NCs:

Nanocarriers

NPs:

Nanoparticles

NLCs:

Nanostructured lipid carriers

NIR:

Near infrared

NO:

Nitric oxide

R8:

Octaarginine

OSM-(PEG-PAEU):

Oligo sulfamethazine conjugated poly (β-amino ester urethane)

OCT:

Optical coherence tomography

OVA:

Ovalbumin

PTX:

Paclitaxel

GNR-PEG:

PEGylated gold nanorods

PDT:

Photodynamic therapy

PTT:

Photothermal therapy

PC:

Phthalocyanine

PVD:

Physical vapor deposition

POC:

Point-of-care

PEDOT:

Poly (3, 4-ethylenedioxythiophene)

PLGA:

Poly D,L-lactic-co-glycolic acid

PLLA:

Poly L-lactic acid

PMVE/MA-PE:

Poly methyl vinyl ether-co-maleic acid pectin

PHEMA:

Poly 2-hydroxyethyl methacrylate

PMVE/MA-PEG:

Poly methyl vinyl ether/maleic acid-poly ethylene glycol

PCL:

Polycaprolactone

PC:

Polycarbonate

PD:

Polydopamine

PEGDA:

Polyethylene glycol diacrylate

PEI:

Polyethylenimine

POM:

Polyformaldehyde

γ-PGA:

Polyglutamic acid

PGA:

Polyglycolic acid

PLA:

Polylactic acid

PMMA:

Polymethyl methacrylate

PS-b-PAA:

Polystyrene-block-poly acrylic acid

PVA:

Polyvinyl alcohol

PDL1:

Programmed cell death ligand-1

PD1:

Programmed cell death receptor-1

PSCA:

Prostate stem cell antigen

PPIX:

Protoporphyrin IX

PB:

Prussian blue

p53 DNA:

p53 tumor suppressor gene

RIE:

Reactive ion etching

RALA:

Arginine-alanine-leucine-alanine

Treg:

Regulatory T cells

R848:

Resiquimod

pRb:

Retinoblastoma protein

SEM:

Scanning electron microscopy

STAT3:

Signal transducer and activity of transcription 3

siRNA:

Small interfering RNA

NaCMC:

Sodium carboxymethyl cellulose

SLNs:

Solid lipid nanoparticles

SC:

Stratum corneum

TT:

Tetanus toxoid

TDD:

Transdermal delivery

TAAs:

Tumor-associated antigens

tdLN:

Tumor-draining lymph node

TYR:

Tyrosinase

TRP-2:

Tyrosinase-related protein-2

US:

Ultrasound

VEGF:

Vascular endothelial growth factor

VA-CNT/PI:

Vertically aligned carbon nanotubes/polyimide

ZnONWs:

Zinc oxide nanowires

ZnPc:

Zinc phthalocyanine

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Acknowledgments

This work supported by grant from Shiraz University of Medical Sciences (SUMS), Shiraz, Iran. The authors wish to thank Mr. H. Argasi at the Research Consultation Center (RCC) of Shiraz University of Medical Sciences for his invaluable assistance in editing this manuscript.

Funding

This article is a part of Mr. Vahid Alimardani thesis funded by Shiraz University of Medical Sciences under supervision of Dr. Samirasadat Abolmaali.

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Authors and Affiliations

  1. Department of Pharmaceutical Nanotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, 71345, Iran

    Vahid Alimardani, Samira Sadat Abolmaali & Ali Mohammad Tamaddon

  2. Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences, Shiraz, Iran

    Samira Sadat Abolmaali & Ali Mohammad Tamaddon

  3. School of Life Sciences, BS Abdur Rahman Crescent Institute of Science and Technology, Chennai, India

    Mohammad Ashfaq

  4. Multidisciplinary Research Institute for Science and Technology, IIMCT, University of La Serena, Benavente 980, La Serena, Chile

    Mohammad Ashfaq

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  1. Vahid Alimardani
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  2. Samira Sadat Abolmaali
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  3. Ali Mohammad Tamaddon
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  4. Mohammad Ashfaq
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Alimardani, V., Abolmaali, S.S., Tamaddon, A.M. et al. Recent advances on microneedle arrays-mediated technology in cancer diagnosis and therapy. Drug Deliv. and Transl. Res. 11, 788–816 (2021). https://doi.org/10.1007/s13346-020-00819-z

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